Endocrinology

EFSUMB Guidelines on Multiparametric Ultrasound Thyroid Nodule Evaluation: PART I.

Thyroid nodules are common incidental findings, but only a small proportion of cases are malignant (4-6.5%) or symptomatic. Numerous follow-up examinations and invasive diagnostic procedures, such as fine-needle aspiration, fine-needle biopsies, and thyroidectomies, are performed, leading to potentially costly and time-consuming diagnostic procedures and overtreatment. Most experts and scientific ...

EFSUMB Guidelines on Multiparametric Ultrasound Thyroid Nodule Evaluation: PART II.

Thyroid nodules are common incidental findings but only a small proportion of cases are malignant (4-6.5%) or symptomatic. Numerous follow-up examinations and invasive diagnostic procedures, such as fine-needle aspiration, fine-needle biopsies, and thyroidectomies, are performed, leading to potentially costly and time-consuming diagnostic procedures and overtreatment. Most experts and scientific s...

Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.

BACKGROUND: Altered stress responses are closely linked to mental disorders, but the role of brain structure in acute cortisol responses to psychosoci...

Beyond Weight: Systems Biology and Precision Medicine Redefine Obesity as a Multidimensional Disease.

BACKGROUND: Traditional weight-centered models do not fully capture the biological complexity of obesity. Systems biology offers a new framework by in...

CT-Free Quantitative Thyroid SPECT Based on Artificial Intelligence: A Prospective Multicenter Noninferiority Clinical Trial.

BACKGROUND: Hybrid single-photon emission computed tomography (SPECT)/computed tomography (CT) is used for the differential diagnosis of thyrotoxicosi...

Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes.

Type 2 diabetes (T2DM) and periodontitis are bidirectionally linked diseases that both involve chronic inflammation; their co‑occurrence represents a ...

Enhancing prediabetes and diabetes detection through a machine learning-enabled self-assessment approach.

OBJECTIVES: Reliable, accessible, noninvasive self-assessment screening for prediabetes/diabetes is lacking, leading to missed opportunities for early...

Integrating generative AI and genetic causal inference identifies metformin as a repurposing candidate for normal tension glaucoma.

The normal tension glaucoma (NTG) has limited drug options since current antiglaucoma medications are mostly designed to decrease intraocular pressure...

The prognostic significance of cholesterol, high-density lipoprotein and glucose (CHG) index in evaluating all-cause mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) individuals: evidence from two cohort studies.

FDG PET in pulmonary sarcoidosis: An update and future aspects.

Pulmonary sarcoidosis is a heterogeneous granulomatous disease with an unpredictable clinical course, in which accurate assessment of disease activity...

Circulating Immune Profiles in ACTH-Dependent Cushing's Syndrome.

OBJECTIVE: ACTH-dependent Cushing's syndrome (CS) causes profound immune dysfunction and severe infections. This study aimed to characterize immune ce...

Study on material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps.

To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on netwo...

A High-Quality Endoscopic Image Dataset with Annotated Recurrent Laryngeal Nerve for AI-Assisted Thyroid Surgery.

The integration of artificial intelligence (AI) into surgical navigation represents a pivotal advancement in modern operative medicine. In endoscopic ...

SoleFusion-Net: an explainable multimodal deep learning framework for diabetic foot syndrome classification in type II diabetes mellitus.

Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining.

The differentiation between pathological subtypes of non-small cell lung cancer (NSCLC) is an essential step in guiding treatment options and prognosi...

Utilizing the transformer mechanism to predict cervical lymph node metastasis in patients with papillary thyroid carcinoma.

RATIONALE AND OBJECTIVE: The status of cervical lymph node metastasis(LNM) in Papillary thyroid carcinoma(PTC) can affect the patient's treatment plan...

From Uncertainty to Precision: Artificial Intelligence-Enhanced Molecular Diagnostics for Thyroid Nodules.

Cutting-edge advances in endocrine therapy for breast cancer (Review).

Endocrine therapy remains one of the primary treatment modalities for estrogen receptor (ER) positive breast cancer, serving a pivotal role in improvi...

SELFormer-guided discovery of xanthohumol and cirsilineol as multi-target natural therapeutics for type 2 diabetes: computational prediction and experimental validation.

Type 2 diabetes mellitus (T2DM) requires multi-target therapeutic approaches addressing both insulin resistance and insulin secretion deficits. Althou...

Interpretable machine learning model for immune-related hyperthyroidism prediction in patients receiving immune checkpoint inhibitors: A retrospective study.