Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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Automated deep learning for detection and measurement of adrenal masses in contrast-enhanced abdominal CT.

OBJECTIVES: Adrenal tumors can be functional or malignant, yet they are often overlooked in abdominal CT. This study aimed to develop and validate a fully automated deep learning model for adrenal mass detection and measurement in contrast-enhanced abdominal CT. MATERIALS AND METHODS: This retrospective study included 415 CT scans with (n = 155) and without (n = 260) adrenal masses for model devel...

Jan 29 2026 41609765

Characterization of Models for Identifying Physical and Cognitive Frailty in Older Adults With Diabetes: Systematic Review and Meta-Analysis.

BACKGROUND: Physical frailty and cognitive frailty are increasingly recognized as critical geriatric syndromes among older adults with diabetes, contributing to adverse outcomes such as disability, hospitalization, and mortality. Early identification of individuals at high risk is therefore essential for timely prevention and intervention. Although a growing number of prediction models have been d...

Jan 29 2026 41610414
Optimizing Early Detection of Diabetic Kidney Disease through Synergistic Biomarkers and Serum Metabolites in Human.

BACKGROUND: Diabetic kidney disease (DKD) progresses to end-stage renal disease more rapidly than chronic kidney disease due to persistent hyperglycem...

Jan 29 2026 41605139
Development of a machine learning-based model for prediction of diabetes risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading chronic liver disorder closely linked to diabetes mellitus (...

Jan 28 2026 41605598
Hierarchical image pyramid transformer framework for automated breast cancer molecular subtyping using tissue microarrays.

The heterogeneity of breast cancer at molecular and histological levels poses significant challenges for precise diagnosis and treatment. Current mole...

Jan 26 2026 41588712
Immune system up-regulation in securely attached infants during early childhood.

Early caregiving relationships shape the coordination of stress and immune systems, yet their biological correlates in early infancy remain insufficie...

Jan 26 2026 41660369
Key evidence for personalised nutrition: a review of randomised controlled trials.

The field of personalised nutrition is growing and is based on the concept that delivering personalised dietary advice will be more effective than gen...

Jan 26 2026 41493072
Deciphering Multitarget Mechanisms of Phytochemical Flavonoids From Traditional Chinese Medicine: Emerging Insights Into Osteoporosis Therapeutics.

Osteoporosis is a common metabolic bone disorder characterized by reduced bone mass and compromised skeletal microstructure, increasing fracture risk....

Jan 25 2026 41581997
Interpretable machine learning model for predicting refeeding syndrome after colorectal cancer surgery.

OBJECTIVE: Refeeding syndrome (RFS) is a common yet frequently overlooked complication during postoperative nutritional support in patients undergoing...

Jan 24 2026 41587656
Bioinspired Multifunctional Hydrogels for Deep Learning-Enabled Wound pH Visual Monitoring and Treatment.

Smart wound dressings capable of real-time environmental monitoring and therapeutic intervention are crucial for managing difficult-to-heal wounds. He...

Jan 24 2026 41579059
Machine learning-based models for preoperative prediction of pituitary adenoma consistency: a systematic review and meta-analysis.

BACKGROUND/OBJECTIVES: The consistency of pituitary adenoma (PA) significantly impacts surgical difficulty and the extent of resection. Machine learni...

Jan 24 2026 41580565
Prognostic value of the triglyceride-glucose index combined with atherogenic index of plasma for all-cause mortality in critically ill patients with chronic heart failure: a machine learning-driven retrospective cohort study.

BACKGROUND: The triglyceride-glucose index (TyG) and atherogenic index of plasma (AIP) are emerging metabolic biomarkers associated with cardiovascula...

Jan 24 2026 41580789
Flavor molecules regulate appetite through the gut-brain Axis: An emerging perspective.

Bioactive flavor molecules (e.g., eugenol, cinnamaldehyde, capsaicin) regulate appetite and energy metabolism via the gut-brain axis, yet their multi-...

Jan 23 2026 41605005
Diagnostic Accuracy of Artificial Intelligence-Enabled Retinal Biomarkers for Detecting Type 2 Diabetes and Prediabetes Among Asian Indians [DART Study].

PURPOSE: To identify retinal microvascular features that distinguish normoglycemia from diabetes mellitus (DM)[Study-1] and prediabetes (PreDM)[Study-...

Jan 23 2026 41574589
Combined Modeling Approaches for Assessing Sodium-Iodide Symporter Inhibition.

The sodium-iodide symporter (NIS, SLC5A5) plays a crucial role in thyroid hormone synthesis. Especially during brain development, correct thyroid sign...

Jan 23 2026 41574740
HelixSide: A Comprehensive Method for Local and Global Orientational Analysis of Proteins.

Understanding the relative orientation of protein secondary structure elements is crucial for elucidating their tertiary organization, function, and i...

Jan 23 2026 41577339
Explainable Hybrid Deep Learning Framework Integrating MobileNetV2, EfficientNetV2B0, and KNN for MRI-Based Brain Tumor Classification.

Magnetic resonance imaging (MRI) is central to noninvasive brain tumor assessment, yet clinical uptake of artificial intelligence depends on both accu...

Jan 23 2026 41578036
Machine learning-based LASSO-Cox model for dementia prediction: the role of midlife cardiometabolic, inflammatory, and genetic risk factors in a US cohort.

PURPOSE: We aimed to identify key midlife dementia predictors and develop a novel machine learning (ML) -enabled risk prediction model. METHODS: Using...

Jan 23 2026 41581843
Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion.

BACKGROUND: Benign adrenal tumours, found in 1-7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., bi...

Jan 22 2026 41576621
Refined query network (RQNet) for precise MRI segmentation and robust TED activity assessment.

Objective.To develop an efficient deep learning framework for precise three-dimensional (3D) segmentation of complex orbital structures in multi-seque...

Jan 22 2026 41442780
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