Public Health & Policy

Ethics

Latest AI and machine learning research in ethics for healthcare professionals.

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Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation

Quantitation of structures is a critical step in analyzing images. Automated segmentation of biological samples remains a central challenge in microscopy, where variations in signal/noise, intensity, texture, and edges hinder accurate delineation of cellular and tissue structures. Adaptations of foundation models such as Segment Anything Model (SAM) remain computationally intensive and require lar...

Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

Enzymes present a sustainable alternative to traditional chemical industries, drug synthesis, and bioremediation applications. Because catalytic residues are the key amino acids that drive enzyme function, their accurate prediction facilitates enzyme function prediction. Sequence similarity-based approaches such as BLAST are fast but require previously annotated homologs. Machine learning approach...

Non-decision time-informed collapsing threshold diffusion model: A joint modeling framework with identifiable time-dependent parameters

Over the past sixty years, evidence accumulation models have emerged as a dominant framework for explaining the neural and behavioral aspects of the p...

HyperBind2: Multi-Shot Learning Enables Progressive Improvement in Computational Antibody Discovery

Antibody discovery remains constrained by resource-intensive experimental screening approaches that offer limited control over critical properties. He...

Multiple Partially Overlapping Neural Modules Orchestrate Conflict Processing

Cognitive conflict is a ubiquitous aspect of our daily life, yet its underlying neural mechanisms remain debated. Competing theories propose that conf...

scCotag: Diagonal integration of single-cell multi-omics data via prior-informed co-optimal transport and regularized barycentric mapping

Recent advances in high-throughput single-cell technologies have enabled characterization of cellular states across distinct omics layers, yielding co...

Leveraging Longitudinal Patient-Reported Outcomes Trajectories to Predict Survival in Non-Small-Cell Lung Cancer

Despite their potential, patient-reported outcomes (PROs) are often underutilized in clinical decision-making, especially when improvements in PROs do...

Privacy-preserving AUC Computation in Distributed Machine Learning with PHT-meDIC

Ensuring privacy in distributed machine learning while computing the Area Under the Curve (AUC) is a significant challenge because pooling sensitive t...

Multi-resolution vision transformer model for skin cancer subtype classification using histopathology slides

Digital pathology has significantly advanced cancer diagnosis by enabling high-resolution visualisation and assessment of tissue specimens. However, t...

PHIVE: A Physics-Informed Variational Encoder Enables Rapid Spectral Fitting of Brain Metabolite Mapping at 7T

Magnetic Resonance Spectroscopic Imaging (MRSI) enables non-invasive mapping of brain metabolite concentrations but remains computationally intensive ...

Ethical and Social Considerations of Applying Artificial Intelligence in Healthcare; a Two-Pronged Scoping Review

Artificial Intelligence (AI) is being designed, tested, and in many cases actively employed in almost every aspect of healthcare from primary care to ...

Designing AI-powered healthcare assistants to effectively reach vulnerable populations with health care services: A discrete choice experiment among South African university students

South African young adults are at increased risk for HIV acquisition and other non-communicable diseases and face significant barriers to accessing he...

Exploring multidrug resistance patterns in community-acquired E. coli urinary tract infections with machine learning

While associations of antibiotic resistance traits are not random in multidrug-resistant (MDR) bacteria, clinically relevant resistance patterns remai...

PREACT-digital: Study protocol for a longitudinal, observational multi-center study on wearable- and EMA- based predictors of non-response to CBT for internalizing disorders

Despite CBT’s status as a first-line treatment, a substantial proportion of patients does not experience sufficient symptom relief. Recent advances in...

Navigating Fairness in AI-based Prediction Models: Theoretical Constructs and Practical Applications

Artificial Intelligence (AI)-based prediction models, including risk scoring systems and decision support systems, are increasingly adopted in healthc...

Socio-Demographic Modifiers Shape Large Language Models’ Ethical Decisions

Large language models’ (LLMs) alignment with ethical standards is unclear. We tested whether LLMs shift medical ethical decisions when given socio-dem...

Screening for anemia using multi-modal machine learning models on smartphones: protocol for a comparative accuracy study in rural India

Anemia, or low blood hemoglobin (Hb), affects one third of the world population, and is particularly prevalent in women and children in lower resource...

Benchmarking transformer-based models for medical record deidentification: A single centre, multi-specialty evaluation

Robust de-identification is necessary to preserve patient confidentiality and maintain public acceptance of electronic health record (EHR) research. M...

Exploring Healthcare Professionals’ Perspectives on Artificial Intelligence in Palliative Care: A Qualitative Study

The use of Artificial Intelligence (AI) methods in palliative care research is increasing. Most AI palliative care research involves the use of routin...

Evaluation of the Bangkok Health Research and Ethics Interest Group: reflecting on the experiences of group members, researchers and facilitators participating in an urban community advisory board in Thailand

The Mahidol Oxford Tropical Medicine Research Unit (MORU), headquartered in Bangkok, conducts research on tropical medicine and global health. MORU wo...

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