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Pain-regulation circuitry as a predictor of chronic pain phenotypes

Background: Chronic pain is a multidimensional condition in which emotional distress, negative expectations, and functional impairment signal greater disease severity. Standard diagnostic categories often fail to capture clinically meaningful heterogeneity, highlighting the need for mechanistic phenotyping. Methods: We studied 159 individuals with fibromyalgia or chronic low back pain and 72 healt...

Rx Norm for Europe - Toward the representation of medicinal products in the OMOP CDM: Graph visualization and validation of two mapping approaches using the OHDSI USAGI tool and LLM

Medication product names in Swiss electronic health records are heterogeneous and often encode multiple attributes (e.g., ingredient, strength, dose form, packaging) in German free text. This limits interoperability and reduces the utility of ATC codes, which do not uniquely identify products. We compared two workflows for mapping Swiss medication products to RxNorm and RxNorm Extension: (i) an Ob...

Towards Efficient Low-rate Image Compression with Frequency-aware Diffusion Prior Refinement

Recent advancements in diffusion-based generative priors have enabled visually plausible image compression at extremely low bit rates. However, existi...

Jan 15 2026 2601.10373v1
Moral psychological exploration of the asymmetry effect in AI-assisted euthanasia decisions.

A recurring discrepancy in attitudes toward decisions made by human versus artificial agents, termed the Human-Robot moral judgment asymmetry, has bee...

Sep 1 2025 40367579
The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.

Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exom...

Aug 1 2025 40374006
Accelerating nonadiabatic molecular dynamics simulations in CdSexTe1-x solar cells with recurrent neural networks.

CdSexTe1-x is one of the most commercially successful absorber materials for thin-film solar cells, where Se doping is crucial for enhancing device ef...

Jul 14 2025 40637181
Formation and Regulation of Calcium Sparks on a Nonlinear Spatial Network of Ryanodine Receptors

Accurate regulation of calcium release is essential for cellular signaling, with the spatial distribution of ryanodine receptors (RyRs) playing a cr...

Modeling Nonradiative Recombination in CsPbI and Ge-Doped Perovskites Via Deep Learning with CNN and Transformer Architectures.

Nonradiative electron-hole recombination is a key factor in the performance bottleneck of perovskite optoelectronic devices, and its rate is highly de...

Jul 10 2025 40576303
Computer-Aided Drug Discovery for Undruggable Targets.

Undruggable targets are those of therapeutical significance but challenging for conventional drug design approaches. Such targets often exhibit unique...

Jul 9 2025 40423592
Understanding support for AI regulation: A Bayesian network perspective

As artificial intelligence (AI) becomes increasingly embedded in public and private life, understanding how citizens perceive its risks, benefits, a...

Semi-Supervised Defect Detection via Conditional Diffusion and CLIP-Guided Noise Filtering

In the realm of industrial quality inspection, defect detection stands as a critical component, particularly in high-precision, safety-critical sect...

BioPortal: an open community resource for sharing, searching, and utilizing biomedical ontologies.

BioPortal (https://bioportal.bioontology.org) is the world's most comprehensive repository of biomedical ontologies. It provides infrastructure for fi...

Jul 7 2025 40357648
MID-INFRARED (MIR) OCT-based inspection in industry

This paper aims to evaluate mid-infrared (MIR) Optical Coherence Tomography (OCT) systems as a tool to penetrate different materials and detect sub-...

Slice-Inference-Assisted Lightweight Small Object Detection Model for Holographic Digital Immunoassay Quantification.

Sensitive and cost-effective detection methods utilizing portable equipment are crucial for applications in food safety inspection, environmental moni...

Jul 1 2025 40540441
The Interplay of Cross-Organ Immune Regulation in Inflammation and Cancer.

Organs dynamically interact with each other through immunomodulation to create a systemic immune response and influence disease progression. While tra...

Jul 1 2025 40529611
Advances in viral vector-based delivery systems for gene therapy: a comprehensive review.

Gene therapy offers a revolutionary approach for treating genetic and acquired disorders by delivering therapeutic genes to target cells. Viral vector...

Jul 1 2025 40454374
Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60.

Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to...

Jul 1 2025 40446543
Integrating AI/ML and multi-omics approaches to investigate the role of TNFRSF10A/TRAILR1 and its potential targets in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival of under 10 % despite current therapies...

Jul 1 2025 40424767
[Rethinking scientific integrity in plastic surgery: Reflections on editorial and institutional responsibilities].

Plastic surgery, by nature an innovative discipline, has historically relied on clinical case reports to advance its techniques. Often unique, these c...

Jul 1 2025 40374450
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