Latest AI and machine learning research in fda general for healthcare professionals.
Deformable image registration (DIR) is an enabling technology in many diagnostic and therapeutic tasks. Despite this, DIR algorithms have limited clinical use, largely due to a lack of benchmark datasets for quality assurance during development. To support future algorithm development, here we introduce our first-of-its-kind abdominal CT DIR benchmark dataset, comprising large numbers of highly ...
MDM2 (Mouse Double Minute 2), a fundamental governor of the p53 tumor suppressor pathway, has garnered significant attention as a favorable target for cancer therapy. Recent years have witnessed the development and synthesis of potent MDM2 inhibitors. Despite the fact that numerous MDM2 inhibitors and degraders have been assessed in clinical studies for various human cancers, no FDA-approved drug ...
We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and con...
The low-altitude economy (LAE) plays an indispensable role in cargo transportation, healthcare, infrastructure inspection, and especially post-disas...
In remote sensing scene classification, leveraging the transfer methods with well-trained optical models is an efficient way to overcome label scarc...
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3'-untranslated regions of target mRNAs, influencing vari...
Drug discovery’s rising costs and complexities require innovative strategies to identify viable therapeutic targets. We developed a computational pipe...
Gene regulation in humans extends beyond the four letter genetic code. Cytosine methylation, in particular, functions as a critical epigenetic switchb...
Against the backdrop of global population growth and the continuous escalation of food demand, the acceleration of agricultural modernization has emer...
Single cell multi-omic investigation opens-up new opportunities to understand mechanisms of gene regulation. Existing methods for inferring transcript...
Alzheimer’s disease (AD) is characterized by region- and patient-specific molecular heterogeneity, which hinders therapeutic design. In this study, we...
Understanding how regulatory DNA elements shape gene expression across individual cells is a fundamental challenge in genomics. Joint RNA-seq and epig...
Estrogen receptor alpha (ERα)-positive (ER+) breast cancers are driven by 17β-estradiol (E2) binding to ERα, which transcriptionally regulates downstr...
Effective treatment of chronic pain remains hindered by the lack of drug delivery systems that simultaneously achieve long-term stability, high spatia...
Resting-state hemodynamic fluctuations are closely linked to gamma-band neural activity, yet the cellular drivers of this neurovascular coupling remai...
Elucidating drug response mechanisms in human melanoma is crucial for improving treatment outcomes. Although scRNA-seq captures gene expression at the...
Existing breast cancer risk models inadequately identify individuals at latent risk, particularly among women without known genetic mutations or famil...
Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and tight junction...
Predictive processes in cognition and the brain are usually modelled as tracking objective event probabilities. However, we know little about how our ...
Exposure to humidifier disinfectants has been linked to an array of pulmonary disorders and diminished lung functionality particularly reduced Forced ...