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Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase.

N-Myristoyltransferase (NMT) catalyzes the transfer of myristate to the amino-terminal glycine of a subset of proteins, a co-translational modification involved in trafficking substrate proteins to membrane locations, stabilization and protein-protein interactions. It is a studied and validated pre-clinical drug target for fungal and parasitic infections. In the present study, a machine learning a...

Nov 15 2016 27766319

30 Years of Robotic Surgery.

The idea of reproducing himself with the use of a mechanical robot structure has been in man's imagination in the last 3000 years. However, the use of robots in medicine has only 30 years of history. The application of robots in surgery originates from the need of modern man to achieve two goals: the telepresence and the performance of repetitive and accurate tasks. The first "robot surgeon" used ...

Oct 1 2016 27177648
DeepChrome: deep-learning for predicting gene expression from histone modifications.

MOTIVATION: Histone modifications are among the most important factors that control gene regulation. Computational methods that predict gene expressio...

Sep 1 2016 27587684
Genome wide predictions of miRNA regulation by transcription factors.

MOTIVATION: Reconstructing regulatory networks from expression and interaction data is a major goal of systems biology. While much work has focused on...

Sep 1 2016 27587697
Mitral Valve Surgery: Current Minimally Invasive and Transcatheter Options.

The mitral valve is a highly complex structure, the competency and function of which relies on the harmonious action of its component parts. Minimally...

Jan 1 2016 27127558
Osteoinductive Activity of DFDBA Materials versus Growth Factors on Gene Expression of MG-63 Cells: An In Vitro Study.

Guided bone regeneration using demineralized freeze-dried bone allograft (DFDBA) and growth factors (GFs) is a current goal in implant dentistry becau...

Jan 1 2016 28094737
[Biologic effects of different concentrations of putrescine on human umbilical vein endothelial cells].

OBJECTIVE: To explore the effects of different concentrations of putrescine on proliferation, migration, and apoptosis of human umbilical vein endothe...

Dec 1 2015 26837252
Potential Mechanisms Underlying Intercortical Signal Regulation via Cholinergic Neuromodulators.

UNLABELLED: The dynamical behavior of the cortex is extremely complex, with different areas and even different layers of a cortical column displaying ...

Nov 11 2015 26558772
Advanced Insulin Bolus Advisor Based on Run-To-Run Control and Case-Based Reasoning.

This paper presents an advanced insulin bolus advisor for people with diabetes on multiple daily injections or insulin pump therapy. The proposed syst...

May 1 2015 24956470
Building an effective ontology for assistive technology.

The aim of this paper was to develop and validate an ontology for one class of assistive technology (AT), namely physically controllable pointing devi...

Jan 1 2015 26294558
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