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Latest AI and machine learning research in fda general for healthcare professionals.

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Early prediction and risk assessment of adverse drug combinations using ensemble learning.

Modern day healthcare has seen an increase in polypharmacy, which is the prescription of multiple drugs as medication to treat illnesses simultaneously. Therefore there is an increased risk of adverse drug reactions resulting from drug-drug interactions. Existing techniques in the field of pharmacovigilance suffer from many drawbacks. Many machine learning approaches using single models face diffi...

Jun 23 2026 42337042

Unveiling the molecular mechanism of Qingwen Baidu decoction against dengue fever: an integrated study of bioinformatic analysis, machine learning and network pharmacology.

Dengue fever, a mosquito-borne disease caused by dengue virus (DENV), has become a global health problem, and no FDA-approved drug is currently available. Qingwen Baidu Decoction (QBD) is used to treat the critical phase of dengue fever in China, but its mechanism of action remains unclear. In this work, we integrated bioinformatics analysis, machine learning, and network pharmacology to investiga...

Jun 23 2026 42332327
Transformer-accelerated discovery of inhibitors targeting the RpsAΔ438 deletion in PZA-resistant tuberculosis.

Tuberculosis is a major global public health problem caused by Mycobacterium tuberculosis. Pyrazinamide (PZA), a key first-line drug, is activated to ...

Jun 22 2026 42332812
Programmable Electrohydrodynamic Printing of Pt-CNTs Nanointerfaces via In Situ Thermal Regulation for High-Fidelity Biosensing.

The accurate simultaneous detection of uric acid (UA) and dopamine (DA) remains a challenge in clinical diagnostics due to the insufficient sensitivit...

Jun 22 2026 42324968
SpliceSelectNet: a hierarchical Transformer-based deep learning model for splice site prediction.

Accurate RNA splicing is essential for gene expression and protein function, yet the mechanisms governing splice site recognition remain incompletely ...

Jun 22 2026 42328788
Barriers and facilitators to developing and implementing artificial intelligence-based clinical decision support in the emergency department: a qualitative study.

OBJECTIVES: This study examined why artificial intelligence (AI)-based clinical decision support tools have had limited clinical translation in the em...

Jun 22 2026 42329568
Integrating experimental biology, computational methods, and artificial intelligence in anticancer drug discovery: Bridging the translational gap.

Cancer remains a leading cause of mortality globally, with the incidence projected to reach 28.4 million new cases annually by 2040. Traditional drug ...

Jun 22 2026 42330856
Patient Trust in AI-generated Medication Information and the Role of Clinical Pharmacists in Preventing Medication-related Safety Risks: A Cross-sectional Survey.

BACKGROUND: To assess patient trust in AI-generated medication information, examine associated behavioral safety risks, and evaluate patient expectati...

Jun 22 2026 42318920
Bone marrow CCR3 dictates eosinophil lineage commitment of CD34⁺ progenitors to orchestrate allergic rhinitis: A composite study.

BACKGROUND: Allergic rhinitis (AR) is a common Th2-mediated inflammatory disease of the nasal mucosa, in which eosinophils serve as pivotal effector c...

Jun 22 2026 42329956
Accelerating drug discovery with mass spectrometry-driven bioanalytical innovations and beyond.

The emergence of structurally complex therapeutic modalities, including bispecific antibodies, antibody-drug conjugates, fusion proteins, incretins, r...

Jun 21 2026 42324885
Quantitative estimation and interpretation of non-technical loss severity in smart grids using RFE-optimized XGBoost regression.

Non-technical losses (NTL) remain a major source of economic risk for electricity distribution utilities. Although extensive research has focused on c...

Jun 21 2026 42324311
Contribution of artificial intelligence in the management of cleft surgeries: a scoping review.

INTRODUCTION: The contribution and future of artificial intelligence (AI) in cleft lip and/or palate (CL/P) need exploration. The aim of this scoping ...

Jun 20 2026 42528887
Optimising biologic therapy in psoriasis: dose adjustment, treatment duration, and tapering-an expert perspective.

INTRODUCTION: Biologic therapies have transformed the management of moderate-to-severe psoriasis; however, long-term treatment requires optimization s...

Jun 20 2026 42323205
Next Generation Digital Morphology: Blast Preclassification in Bone Marrow Aspirates.

INTRODUCTION: Morphologic evaluation of peripheral blood (PB) smears and bone marrow aspirates (BMA) remains central to the diagnosis of acute leukemi...

Jun 19 2026 42322062
Local performance and fairness testing of an AI Scribe in a paediatric developmental assessment clinic in South Australia: a silent trial protocol.

INTRODUCTION: Any tool that can reduce the administrative burden on healthcare providers while preserving safe, accountable and high-quality medical d...

Jun 19 2026 42320966
Regulating digital surgery to balance safety and innovation: a SAGES white paper.

BACKGROUND: Digital surgery technologies, including robotic systems, artificial intelligence (AI) algorithms, augmented reality platforms, and advance...

Jun 19 2026 42321466
Unclonable Three-Level Holograms for Two-Factor Visual Authentication via One-Step Cascade-Nanostructure Imprinting.

Digital authentication technologies are increasingly threatened by the rapid advance of artificial intelligence and sophisticated cyberattacks. Agains...

Jun 18 2026 42313001
Targeted maximum likelihood estimation (TMLE) in regulatory submissions and research: a landscape analysis.

Targeted Maximum Likelihood Estimation, also referred to as Targeted Minimum Loss Estimation (TMLE), is a statistical method that enables causal infer...

Jun 17 2026 42307456
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