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AXIS: a Lab-in-the-Loop machine learning approach for automated detection of macromolecular crystals.

Macromolecular crystallography provides mechanistic understanding of biological processes and can be applied in drug design. Nowadays, the use of robotic systems for crystal growth and diffraction analysis is widespread and high-throughput protein-to-structure pipelines for ligand and fragment screening are revolutionizing the field. However, the identification of crystals is still largely carried...

May 1 2026 41854216

Advancing IBD Management: A Literature Review on the Role of Non-Invasive Blood-Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment.

Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their utility in routine monitoring and clinical trials. Blood-ba...

May 1 2026 42045784
SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold-Mediated Regulation.

Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, se...

May 1 2026 42045927
Trends in accuracy management of continuous glucose monitoring systems.

Continuous glucose monitoring (CGM) has markedly advanced diabetes care by enabling real-time visualization of glycaemic variability, prevention of hy...

Apr 30 2026 42078491
Machine learning method for the prediction of Bedaquiline-resistant Mycobacterium tuberculosis.

The study addresses the increasing resistance to the FDA-approved drug Bedaquiline (BDQ) in Mycobacterium tuberculosis (MTB). The absence of any defin...

Apr 30 2026 42061986
Current and Emerging Therapies Targeting the IL-23/IL-17 Axis in Psoriasis.

Over the past two decades, experimental and clinical evidence has established the interleukin-23 (IL-23)/interleukin-17 (IL-17) axis as a key mediator...

Apr 30 2026 42059024
The role of autophagy in ocular health: mechanisms, pathologies, and therapeutic strategies.

Autophagy is a self-digestive process in which cellular components are degraded and recycled to maintain homeostasis and cope with stress. When cells ...

Apr 30 2026 42063162
An integrative machine learning and structure-driven drug repositioning strategy for human IRAK4-targeted cancer therapy.

The upregulation of interleukin-1 receptor-associated kinase 4 (IRAK4) drives pro-tumorigenic signaling across various malignancies. Currently availab...

Apr 30 2026 42059929
Neural Stem Cell-Derived Extracellular Vesicles: The Next Frontier in Neurological and Neurodegenerative Diseases.

The present manuscript provides a comprehensive overview of neural stem cell (NSC)-derived extracellular vesicles (NSC-EVs( as a cell-free approach to...

Apr 30 2026 42060081
DualFusionNet: A fusion-based dual architecture for visual quality control on fabric surfaces.

Zippers are essential in fashion and beyond. Found on jackets, shoes, and bags, they provide a versatile and practical opening and closing mechanism t...

Apr 29 2026 42054394
Quantitative whole-body measurement of inflammothrombotic immunologic response disease using Fleming method for tissue and vascular differentiation and metabolism.

BACKGROUND: Precision theranostics in nuclear medicine requires reproducible, calibrated quantification of tissue perfusion, and metabolism. This stud...

Apr 28 2026 42046542
Modulating empathy with tDCS: dissociable roles of rTPJ and lDLPFC.

BACKGROUND: Empathy relies on distinct but interacting processes for representing others' states and regulating self-oriented affect. Neuroimaging stu...

Apr 28 2026 42047109
Application of artificial intelligence in paediatric oncology imaging.

Paediatric oncology relies heavily on medical imaging for diagnosis, treatment planning, and longitudinal disease monitoring. Yet the field faces uniq...

Apr 28 2026 42047765
Single-cell chromatin accessibility and cis-regulatory element analyses in plants using the scPlantReg platform.

Understanding gene regulation is fundamental to plant improvement. However, the lack of plant-specific single-cell assay for transposase-accessible ch...

Apr 28 2026 42050196
Accurate profiling of single-cell alternative transcript start sites by correcting RNA degradation.

The generation of transcript variants via alternative utilisation of transcription start sites (TSSs) is a pivotal regulatory mechanism in physiologic...

Apr 28 2026 42045202
Advances in Digital Cytopathology and Artificial Intelligence Applications.

Cytopathology is the first field of pathology in which artificial intelligence (AI) models were successfully developed and commercialized for routine ...

Apr 27 2026 42046894
An image-based food quality analysis framework driven by large language models.

Although computer vision approaches based on machine learning (ML) and deep learning (DL) have been applied to image-based food quality analysis, they...

Apr 27 2026 42046957
Spectroscopic control of fish products: simultaneous recognition of species and thawed status in large-scale distribution.

In the context of globalized food production, traceability is a key requirement in the fisheries sector, particularly for prepared and packaged fish p...

Apr 27 2026 42047407
Understanding AI risks from its characteristics and NMPA regulation perspectives.

AI is reshaping medical research and healthcare delivery, yet the translation of AI innovations into clinically approved medical devices remains limit...

Apr 27 2026 42043493
Development of a community home-based dual-supplier cooperation care model for people with dementia based on an intelligent decision-assistance system: protocol of a 1-year randomised controlled trial in China.

INTRODUCTION: Dementia imposes significant care and financial burdens on families and countries globally. While high-quality home-based care is crucia...

Apr 27 2026 42044955
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