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Latest AI and machine learning research in fda general for healthcare professionals.

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Concept of premature mortality: protocol for a scoping review.

INTRODUCTION: Premature mortality (PM) is a concept applied in public health, epidemiology, medicine, demography and economics. Its conceptualisations vary across disciplines and often rely on implicit normative assumptions. A scoping review is needed to build a typology to systematise PM conceptualisations and make their assumptions explicit. METHODS AND ANALYSIS: We will conduct a scoping review...

Apr 27 2026 42044964

Antimycobacterial Peptides: From Natural Product Discovery to AI Guided Design.

Mycobacterial pathogens remain major global health threats, exacerbated by both rapid acquisition of antibiotic resistance and the formidable drug diffusion barrier presented by the rigid mycomembrane. These challenges have renewed interest in antimycobacterial peptides (AMyPs), a diverse class of short amphiphilic sequences capable of rapidly killing both drug-sensitive and drug-resistant mycobac...

Apr 27 2026 42045115
Medicinal and Edible Plants for the Management of Inflammatory Bowel Disease: Synergistic Modulation of the Microbiota-Metabolite-Immune Axis.

Inflammatory bowel disease (IBD) is a chronic condition driven by the intertwined interplay of gut dysbiosis, immune perturbation, and metabolic imbal...

Apr 27 2026 42036630
Biological effects of ultrasonic cavitation in cancer therapy: from physics to mechanobiology.

The therapeutic efficacy of systemic treatments in cancer therapy is invariably limited by the biophysical barriers, including vascular endothelial ba...

Apr 25 2026 42044865
Deep learning-based double-sided fudge detection system with integrated physical components.

This study proposes an automated defect detection system for large-scale fudge production, addressing the limitations of manual inspection, which is b...

Apr 25 2026 42034913
Plasma multi-omics profiling unravels molecular alterations and biomarker panels during recovery from severe coronavirus disease 2019: a pilot study.

BACKGROUND: The potential multidimensional molecular alterations during recovery of severe patients with coronavirus infectious disease (COVID-19) rem...

Apr 25 2026 42034967
Non-invasive CT-based Deep Learning for Human Papillomavirus Status Prediction in Oropharyngeal Cancer.

RATIONALE AND OBJECTIVES: Human papillomavirus (HPV) status is a critical biomarker for treatment planning and patient management in oropharyngeal can...

Apr 25 2026 42036264
Nanointerface-Engineered Triboelectric Nanocomposite for Self-Powered Intelligent Motion Decoding.

Real-time motion intelligence from wearable systems requires efficient conversion of biomechanical energy into stable and information-rich electrical ...

Apr 24 2026 42028707
Hierarchical coordinated scheduling algorithm for reactive power and voltage in cross-regional power grids based on multi-agent reinforcement learning.

To address the challenges of strong dynamic coupling, action space dimension explosion, and voltage imbalance in reactive power and voltage scheduling...

Apr 24 2026 42030270
A structure-based virtual screening approach to identify novel anaplastic lymphoma kinase inhibitors.

CONTEXT: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that plays a crucial role in cellular signaling and is implicated in several c...

Apr 23 2026 42024204
A Datasheet for the INSIGHT Moorfields Cornea Anterior Segment Dataset (CADMUS).

PURPOSE: To describe Cornea Anterior Segment Dataset from Moorfields via INSIGHT (CADMUS), a large multimodal anterior segment imaging dataset develop...

Apr 22 2026 42256008
Thalamocortical regulation of prefrontal stability enables abstract rule generalization.

Our ability to generalize abstract rules to new situations is a cognitive hallmark, yet its neural basis is unclear. We identified a thalamocortical c...

Apr 22 2026 42018611
Edge-enabled IoT framework for real-time tobacco quality monitoring.

Tobacco quality inspection plays a vital role in ensuring standardized processing, reducing economic losses, and improving industrial automation. Howe...

Apr 22 2026 42020563
NSUN2 restrains renal fibrosis via m5C-stabilized GPX4 and ferroptosis inhibition.

BACKGROUND: Renal fibrosis (RFib) is a final common pathway in chronic kidney disease (CKD) progression. Although 5-methylcytosine (m5C) RNA modificat...

Apr 21 2026 42025889
Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Alt...

Apr 21 2026 42081487
FDA-authorized oncology artificial intelligence and machine learning devices and their clinical evidence: A cross-sectional analysis.

BACKGROUND: Artificial intelligence (AI) and machine learning (ML) tools are increasingly embedded in cancer care, yet the scope of U.S. Food and Drug...

Apr 21 2026 42025919
Single-Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5-Mediated M1 Polarization.

BACKGROUND: Thoracic aortic aneurysm (TAA) is a life-threatening disease with limited therapeutic options, largely due to an incomplete understanding ...

Apr 21 2026 42011731
From pixels to pathology: how artificial intelligence mammographic risk scores capture tumor biology through imaging.

OBJECTIVES: To characterize clinical-pathologic tumor features associated with artificial intelligence (AI)-generated risk scores from prior-year scre...

Apr 21 2026 42014495
Ethical, Legal, and Social Implications of Artificial Intelligence in Oral Oncology: A Narrative Review.

BACKGROUND: Artificial intelligence (AI) has emerged as a transformative tool in oral oncology, enabling earlier detection of oral potentially maligna...

Apr 20 2026 42528759
Target identification and assessment in the era of AI.

Drug discovery and development is time-intensive, expensive and laden with risk. Identifying the right drug targets is crucial for increasing the prob...

Apr 20 2026 42009769
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