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Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change.

Soybean (Glycine max L.), a key global source of protein and oil, is increasingly threatened by climate change-driven environmental stresses, including drought, salinity, waterlogging, temperature extremes, nutrient limitations, and pathogen pressures, all of which jeopardize yield stability and global food security. Recent advances in functional genomics, high-throughput phenotyping, and computat...

Apr 20 2026 42010761

Artificial intelligence (AI)-assisted ultrasound in clinical trials: Endpoint automation, decentralized monitoring, and regulatory readiness.

Ultrasound is among the most widely used imaging modalities in clinical trials, and yet its dependence on operator skill and equipment settings has historically limited the reproducibility of ultrasound-based endpoints in multi-center studies. Artificial intelligence (AI) now addresses this limitation across two complementary dimensions: automated measurement algorithms that quantify cardiac funct...

Apr 20 2026 42002939
Combining cutting edge computational and experimental methods for targeting kras mutations in non-small cell lung cancer.

INTRODUCTION: Historically, KRAS mutations have been notoriously difficult to target despite their status as the most commonly mutated oncogene in the...

Apr 20 2026 42003513
Advancing precision medicine in pancreatic cancer using novel biomarkers and clinical targets.

Precision-guided therapy is imperative in the battle against pancreatic ductal adenocarcinoma (PDAC), one of the most lethal solid malignancies with l...

Apr 19 2026 42008879
Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi-Fidelity Techniques.

The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remai...

Apr 19 2026 42003014
[Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].

Cranio-maxillofacial bone defects resulting from trauma, tumors, infection, or congenital malformations not only severely impair patients' physiologic...

Apr 18 2026 41978395
Deep learning and hyperspectral imaging for non-destructive amino acid detection in live carp fillets.

Rapid and non-destructive inspection of fillet nutritional quality is essential for selecting high-value live fish prior to processing, yet no such me...

Apr 17 2026 42116429
Rational and Multidimensional Optimization of Nanozyme Catalytic Performance.

Nanozymes are a class of nanomaterials with intrinsic biocatalytic activities. Compared to natural enzymes, they offer superior stability, precise str...

Apr 17 2026 41995715
Independent bone-level diagnostic accuracy study of an AI tool for detecting appendicular skeletal fractures on radiographs.

OBJECTIVES: To perform an in-depth evaluation of the diagnostic test accuracy of a commercially available AI tool for assistance in fracture detection...

Apr 17 2026 41995742
Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.

BACKGROUND: Chronic pancreatitis (CP) is a progressive inflammatory disorder characterized by debilitating chronic pain and substantial healthcare bur...

Apr 17 2026 41998114
An explainable multi-head attention network for healthcare IoT threat detection based on the MedDefender-MHAN framework.

The rapid proliferation of Internet of Medical Things (IoMT) devices in healthcare environments has created critical cybersecurity vulnerabilities tha...

Apr 17 2026 41996403
Overcoming barriers to delivery of biologics by novel approaches and, advanced delivery systems.

Biologics is emerging as fastest growing field of drug development offering specificity and high therapeutic potential. However, their therapeutic eff...

Apr 16 2026 41999768
When work, study, and AI collide: Cognitive dissonance and emotional regulation in part-time translation master's students.

In the era of generative artificial intelligence (AI), translation education is undergoing profound changes, posing new cognitive and emotional challe...

Apr 16 2026 41997073
Reimagining human-centric drug development with new approach methodologies.

Despite unprecedented technological progress, most drug candidates continue to fail in clinical trials, reflecting a persistent gap between preclinica...

Apr 16 2026 41990130
Research advances in machine learning-aided accurate prediction of the impact of exogenous substances on anaerobic digestion.

Exogenous substances (including additives and pollutants), as key factors influencing anaerobic digestion (AD) systems, exert dual effects on microbia...

Apr 15 2026 41997242
Prospective Data Curation Enables High-Performance Artificial Intelligence for Diabetic Retinopathy Screening in a Resource-Limited Setting.

PURPOSE: To determine whether a high-quality, prospectively curated dataset can, by itself, enable the development of robust and clinically effective ...

Apr 15 2026 42222586
Machine learning-based multi-omic analysis identifies CEP55, DLGAP5, and EZH2 as regulated cell death biomarkers linked to immunotherapy resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) often exhibits limited responsiveness to immune checkpoint inhibitors (ICIs), largely due to an immunosuppressive tumor...

Apr 15 2026 41984188
Implementation and User Evaluation of an On-Premise Large Language Model in a German University Hospital Setting: Cross-Sectional Survey.

BACKGROUND: Large language models (LLMs) are increasingly used by employees at university hospitals for information retrieval or decision support. Sel...

Apr 15 2026 41984850
Dietary nutritional strategies for circadian rhythm regulation: advances, challenges and future directions.

The escalation of urban light pollution and the trend toward a globalized lifestyle have led to a notable increase in circadian rhythm disruption (CRD...

Apr 14 2026 41982068
Imaging Immune Heterogeneity in Nasopharyngeal Carcinoma: A Multidimensional Radiomics Perspective.

RATIONALE AND OBJECTIVES: Nasopharyngeal carcinoma (NPC) is characterized by a distinctive virologic and immunologic profile, in which Epstein-Barr vi...

Apr 14 2026 41986218
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