FDA General

From structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy.

Migraine is a prevalent and disabling neurological disorder that imposes a substantial global disease burden, particularly among women of childbearing age. Although therapies targeting the calcitonin gene-related peptide (CGRP) pathway have improved migraine management, a considerable proportion of patients exhibit an insufficient clinical response, highlighting the importance of CGRP-independent ...

Beyond spectroscopy: Machine vision as the future of non-destructive testing in 3D-printed pharmaceuticals.

3D Printing (3DP) has revolutionized personalized medicine by enabling the production of patient-specific dosage forms and adaptable drug delivery systems. However, despite these advances, 3DP presents significant challenges in quality control (QC), particularly as traditional methods may not be suitable for small-scale or on-demand manufacturing. To address these challenges, it is essential to de...

Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.

Cell migration underlies immune surveillance, tissue repair, embryogenesis, and-when dysregulated-tumor metastasis. Yet unlike proliferation, which ca...

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet the extent of contribution from posttranscripti...

G-quadruplexes and i-motifs: Emerging regulatory elements in plant genomes.

G-quadruplexes (G4s) and i-motifs (iMs) are emerging as key cis-regulatory elements in plant genomes, functioning at both DNA and RNA levels. This rev...

Climate driven drought risk and machine learning approaches for urban resilience and sustainable water governance.

Drought is thought of as one of the gravest climate-related hazards of the agro-dependent regions facing water stress like Pakistan where socio-econom...

Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.

BACKGROUND: Obesity is a major health concern linked to chronic conditions such as diabetes and cardiovascular disease. However, most neurological stu...

Leveraging proteomics and machine learning for mechanism and biomarker discovery on glioma progression and transformation: from LGG to GBM.

BACKGROUND: Glioma was the most common malignant tumor of the central nervous system in adults. Low-grade gliomas (LGGs) have a potential of grade pro...

Comprehensive Analysis of Bulk RNA-seq, Machine Learning, Mendelian Randomization, and Single-Cell Sequencing Unravels SLC22A3 as a Solute Carrier Superfamily-Associated Biomarker in Atherosclerosis.

Growing evidence implicates solute carrier (SLC) superfamily in atherosclerosis (AS) pathogenesis. This study identified SLC22A3 as a novel AS biomark...

The essential role of methylation in maize (Zea mays) defense against the seed-colonizing fungus Aspergillus flavus.

UNLABELLED: The interaction between maize (Zea mays) and Aspergillus species poses a huge threat to global food safety due to the production of aflato...

Harnessing the Power of artificial intelligence for clinical trials in cancer.

INTRODUCTION: Cancer research has become increasingly data-intensive, with digital pathology, imaging, and genomic sequencing generating vast, heterog...

Dysbiosis of fecal virome in pediatric Crohn's disease and its dynamic changes during infliximab therapy.

UNLABELLED: The gut virome is an emerging but underexplored component of the human microbiota, especially in pediatric Crohn's disease (CD). This stud...

Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.

BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lackin...

Precise oxygen therapy to emphysema patients by fuzzy-based gain tuning control of set-point regulated MRAC.

Emphysema, a primary component of chronic obstructive pulmonary disease (COPD), causes progressive dyspnea through the destruction of alveolar membran...

Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies.

Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of d...

Artificial intelligence in pharmaceutical manufacturing: Applications, case studies, and GxP implementation considerations.

Artificial intelligence (AI) and machine learning (ML) applications are starting to be employed within the pharmaceutical manufacturing industry to cr...

The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review).

The interaction between autophagy and ferroptosis has resulted in the identification of novel approaches for the treatment of lung cancer (LC). The tw...

Current State of Artificial Intelligence Adoption and Implementation in Neuroradiology Departments: Insights from a U.S. National Survey.

BACKGROUND AND PURPOSE: Artificial intelligence (AI) is rapidly transforming medical imaging, yet its integration into neuroradiology remains uneven. ...

Strategic SA-UNet: Integrating self-attention blocks into U-Net for efficient crack segmentation.

Accurate crack segmentation plays a crucial role in ensuring safety and mitigating disaster risks during road inspections and structural health monito...

Spatiotemporal dynamics and future predictions of ecosystem service synergies and trade-offs in China.

Ecosystems provide extensive benefits to human well-being through food production, climate regulation, and cultural services. Climate change and socio...