FDA General

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists.

RNA metabolism in kinetoplastid protists (Kinetoplastea), including trypanosomes and Leishmania, involves unique post-transcriptional mitochondrial RNA editing that creates translatable mRNAs through uridine (U) insertions and deletions (U-indels) directed by antisense guide RNAs (gRNAs). Like other biological processes that require specific RNA targeting, this system faces several challenges beyo...

Regenerative and Stem Cell-Based Therapies for Arthritis: Harnessing Mesenchymal Stem Cells, Exosomes, and Bioengineered Scaffolds for Functional Joint Repair.

Arthritis, encompassing degenerative disorders such as osteoarthritis (OA) and autoimmune diseases like rheumatoid arthritis (RA), remains a leading cause of chronic pain, disability, and socioeconomic burden worldwide. Conventional pharmacological and surgical therapies primarily offer symptomatic relief without addressing the underlying degeneration of cartilage and bone. Recent advances in rege...

AI in clinical trials: Current status, challenges, and future directions for emergency infectious disease clinical trials -Insights from the 2025 iCROWN Symposium.

Artificial intelligence (AI) has the potential to transform how drug development and clinical trials are conducted. The 2025 Infectious Disease Clinic...

Virtual Control Groups in Nonclinical Research: A Re-analysis of 20 Studies Using Virtual Control Group Data.

Animal models are crucial in biomedical research, particularly in pharmaceutical discovery and safety testing. Recent legislative updates and regulato...

Organic Optoelectronic Memristor Inspired by Insect Ultraviolet Vision for Attention Mechanism Simulation.

The rapid evolution of modern technology is propelling artificial intelligence into a transformative phase, where visual information processing has be...

Dynamic Insights into Cellular Mechanics and Membrane Undulations in Vascular Smooth Muscle Cells.

Dynamic oscillations in cell mechanics are fundamental yet poorly understood features of living cells. In vascular smooth muscle cells (VSMCs), such o...

Computational and AI-Driven Ecosystem for Structure-Based Covalent Drug Discovery.

ConspectusThe field of covalent drug discovery has witnessed a remarkable resurgence in recent years, a trend underscored by the approval of more than...

Impact of quality routine health data utilisation on health service delivery outcomes in low-income and middle-income countries: a systematic review protocol.

BACKGROUND: Evidence-based decision-making in healthcare relies heavily on routine health information. However, in many low-income and middle-income c...

Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application.

Mesenchymal stromal cells (MSCs) possess potent immunomodulatory, pro-angiogenic, and regenerative capacities, offering broad clinical promise in rege...

New treatments to rabies virus infections.

Rabies disease is the deadliest of all virus infections. Till now, vaccination is the most effective and reliable treatment for controlling rabies. Ho...

Radiopharmaceuticals: Status, Regulatory Landscape and Future Perspective.

Radiopharmaceuticals are biologically active molecules labeled with radionuclides that have advanced the possibility of the nuclear medicine. They sup...

Applications of artificial intelligence for real-world evidence generation: a protocol for a living scoping review.

INTRODUCTION: Artificial intelligence (AI) is rapidly evolving, offering an expanding suite of capabilities that go beyond the traditional focus on pr...

A dataset of midpalatal suture maturation stage in cone-beam computed tomography.

In the field of orthodontics, the degree of fusion of the midpalatal suture (MPS) is a crucial factor in determining the most appropriate maxillary ex...

Anticipating Moral and Economic Considerations, Opportunities, and Potential Frictions for AI in Medical Imaging: Multistakeholder Cocreation Study.

BACKGROUND: Artificial intelligence (AI) promises to significantly impact daily radiology practices. Numerous studies have already been conducted that...

Exploring Reddit Discourse and Information Needs Surrounding Extreme Heat: Topic, Sentiment, and Engagement Analysis.

BACKGROUND: As Canada's climate changes, extreme heat events have become more frequent, a trend that is expected to continue. Extreme heat can lead to...

Precision nutrition and food biomanufacturing for space missions: Toward intelligent and bioregenerative life-support systems.

Long-duration spaceflight presents unique physiological and nutritional challenges due to factors such as microgravity, radiation, confinement, and ci...

Generative artificial intelligence in dementia care: a scoping review protocol on nursing roles, experiences and ethical perspectives.

INTRODUCTION: Generative artificial intelligence (GAI), including large language models and multimodal generative systems, is rapidly emerging in heal...

Role of lactic acid-mediated ALKBH5 in depression induced by blue light exposure at night.

Artificial light at night (ALAN) has been classified as a significant environmental endocrine disruptor. Excessive exposure to ALAN has associated wit...

Generative AI in EFL contexts: Q-methodological analysis of cognitive dissonance patterns and self-regulation strategies among Chinese tertiary learners.

Generative Artificial Intelligence (GenAI) has recently attracted growing attention in English as a Foreign Language (EFL) education, offering opportu...

Is the FDA regulation of cardiology AI devices supporting cardiovascular innovation: a scoping review.

BACKGROUND: Artificial intelligence (AI) and machine learning (ML) have shown immense potential in cardiology, leveraging data-driven insights to enha...