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Privacy-Preserving Glycemic Management in Type 1 Diabetes: Development and Validation of a Multiobjective Federated Reinforcement Learning Framework.

BACKGROUND: Effective diabetes management requires precise glycemic control to prevent both hypoglycemia and hyperglycemia, yet existing machine learning (ML) and reinforcement learning (RL) approaches often fail to balance competing objectives. Traditional RL-based glucose regulation systems primarily focus on single-objective optimization, overlooking factors such as minimizing insulin overuse, ...

Jul 4 2025 40614090

The Hidden Crux of Correctly Determining Octanol-Water Partition Coefficients.

The partitioning of molecules between an aqueous and an organic medium is of major interest for pharmaceutical development and the chemical industry. It characterizes the impact of substances to the environment and to humans, e.g., their accumulation in living organisms. It is usually quantified in terms of the octanol-water partition coefficient of these substances. Although this is a clearly de...

Jul 3 2025 40609971
Drug-target interaction/affinity prediction: Deep learning models and advances review.

Drug discovery remains a slow and expensive process that involves many steps, from detecting the target structure to obtaining approval from the Food ...

Jul 2 2025 40609289
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.

Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment resp...

Jul 2 2025 40603860
Assessment of drug induced hyperuricemia and gout risk using the FDA adverse event reporting system.

Hyperuricemia, the key pathological basis of gout, is increasingly prevalent worldwide. While lifestyle factors contribute, various medications also p...

Jul 2 2025 40596361
Treatment Response Evaluation in Prostate Cancer Using PSMA PET/CT.

In recent years, there has been a headlong rush into the use of prostate-specific membrane antigen (PSMA)-targeted PET for the staging and restaging o...

Jul 1 2025 40473460
Therapeutic horizons in metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, is now a leading cause of chronic liver disease w...

Jul 1 2025 40590228
The Role of Precision Nutrition in Kidney Disease.

Precision nutrition utilizes an individualized approach in which dietary interventions are tailored according to patients' genetic, biologic, and envi...

Jul 1 2025 40591436
A novel artificial intelligence-based system for quality monitoring during esophagogastroduodenoscopy: a multicenter randomized controlled study.

Esophagogastroduodenoscopy (EGD) is the pivotal procedure for diagnosis of upper gastrointestinal (UGI) lesions. However, significant variation in EGD...

Jul 1 2025 40592476
Development and validation of an AI-enabled oral score using large-scale dental data.

This research introduces Oral Score Basic (OS-B), a novel Artificial Intelligence (AI) derived methodology designed to provide a comprehensive, object...

Jul 1 2025 40593131
A real-world data analysis of montelukast in FDA Adverse Event Reporting System (FAERS) database.

BACKGROUND: Montelukast(MTK) is a leukotriene receptor antagonist widely used clinically for treating asthma and rhinitis. However, many adverse event...

Jul 1 2025 40598639
Boosting Checkpoint Blockade Immunotherapy with T Cell Membrane Redox Homeostasis Regulation and Deep Learning Enhanced NIR-II Imaging.

Immune checkpoint blockade therapy has revolutionized clinical oncotherapy by intercepting immunosuppressive pathways in tumor tissues. Nevertheless, ...

Jun 30 2025 40583483
Artificial Intelligence in Gastrointestinal Endoscopy: The Japan Gastroenterological Endoscopy Society Position Statements.

Research and development of artificial intelligence (AI) in the field of gastrointestinal endoscopy is progressing rapidly. In Japan alone, there are ...

Jun 30 2025 40586266
Biologics for severe asthma: deciphering what is best for the patient.

INTRODUCTION: Choosing the right biologic for the right patient is challenging. It requires evaluating patient characteristics and disease manifestati...

Jun 30 2025 40556115
Practical applications of AI in body imaging.

Artificial intelligence (AI) algorithms and deep learning continue to change the landscape of radiology. New algorithms promise to enhance diagnostic ...

Jun 27 2025 40576669
Walking Backward to Ensure Risk Management of Large Language Models in Medicine.

This paper examines in what way providers of specialized Large Language Models (LLM) pre-trained and/or fine-tuned on medical data, conduct risk manag...

Jun 27 2025 40574504
Clinical efficacy of AI in lung SABR planning: A comparative retrospective analysis.

This study evaluated the effectiveness of an integrated Artificial Intelligence (AI) planning tool in a lung stereotactic ablative body radiotherapy (...

Jun 26 2025 40579326
Development of an anomaly detection system for Gibbs artifact identification in amyloid PET imaging.

The PET Imaging Site Qualification Program for amyloid positron emission tomography (PET) in Japan includes visual evaluation of the cylinder phantom....

Jun 25 2025 40560355
Evaluating a brief smartphone-based stress management intervention with heart rate biofeedback from built-in sensors in a three arm randomized controlled trial.

Perceived stress is prevalent in industrial societies, negatively impacting mental health. Smartphone-based stress management interventions provide ac...

Jun 23 2025 40550871
Seminars in epileptology: How to diagnose status epilepticus in adults and children.

Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation ...

Jun 18 2025 40528536
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