FDA General

Genome-wide annotation and comparative analysis of miniature inverted-repeat transposable elements (MITEs) in six pear species.

Through multi-faceted comparative analysis of MITEs across six pear genomes, we revealed their distribution patterns, functional impacts and their significant role as genomic origins for miRNAs, with copy number being the most critical factor for MITE-miRNA transformation, providing valuable insights for future research. Miniature inverted-repeat transposable elements (MITEs) are prevalent in plan...

Analysis of the neural mechanisms of social anxiety based on EEG features and machine learning and construction of a diagnostic model.

Social anxiety is a common psychological problem, and its accurate diagnosis and investigation of underlying neurophysiological mechanisms are of significant importance. This study aims to explore the neuroelectrophysiological characteristics and diagnostic value of social anxiety by integrating event-related potentials (ERP), event-related spectral perturbation (ERSP), and machine learning method...

The Future of Automated Insulin Delivery Systems.

Automated insulin delivery (AID) systems have revolutionized diabetes care by integrating continuous glucose monitoring (CGM), insulin pumps, and adva...

Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis.

Branching morphogenesis orchestrates organogenesis in many tissues, including the kidney, where ureteric bud (UB) branching determines kidney size and...

Psychedelics, entactogens and psychoplastogens for depression and related disorders.

Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, L...

From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynami...

Semantic Search of FDA Guidance Documents Using Generative AI.

INTRODUCTION: Generative artificial intelligence (AI) has the potential to transform and accelerate how information is accessed during the regulation ...

An Artificial Intelligence Solution for Automated Dental Inspection and Charting.

BACKGROUND: Visual inspection and documentation (charting) of findings are critical components in dental practice. However, manual charting is tedious...

2D van der Waals heterostructure memristors: from band structure regulation to neuromorphic computing applications.

Two-dimensional (2D) materials and their van der Waals heterostructures (vdWHs) have shown tremendous potential in the fields of memristors and neurom...

Targeting Mycobacterial Dormancy Survival Regulator (DosR) With Generative Artificial Intelligence and Omics Methods.

Tuberculosis, driven by Mycobacterium tuberculosis, remains a global health challenge due to the pathogen's ability to enter a dormant state, evading ...

Development of a circadian-related prognostic signature highlights RBM17 as a stemness regulator in liver cancer.

The liver exhibits extensive circadian regulation among organs. Epidemiological studies have substantiated that disruptions in circadian rhythm consti...

Exploring the molecular mechanisms of lactylation-related biological functions and immune regulation in sepsis-associated acute kidney injury.

Lactylation, a novel post-translational modification, has been implicated in various pathophysiological processes; however, its role in sepsis-associa...

Analytical Comparison of Commonly Used Laboratory-Developed Tests for the Assessment of Ki-67 in Breast Carcinoma With an FDA-Approved Benchmark.

Ki-67 immunohistochemistry (IHC), a commonly used assay for breast cancer risk prognostication, has significant inter-laboratory heterogeneity. This s...

Advancements and Applications of Hyperpolarized Xenon MRI for COPD Assessment in China.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality in China, highlighting the importance of early di...

SCATrans: semantic cross-attention transformer for drug-drug interaction predication through multimodal biomedical data.

Predicting potential drug-drug interactions (DDIs) from biomedical data plays a critical role in drug therapy, drug development, drug regulation, and ...

Prediction of air temperature and humidity in greenhouses via artificial neural network.

Accurate prediction of greenhouse temperature and relative humidity is critical for developing environmental control systems. Effective regulation str...

Single-cell sequencing and machine learning reveal the role of dioxin-interacting genes in HCC prognosis and immune microenvironment.

Dioxins are persistent environmental pollutants that bioaccumulate in the food chain, posing significant risks to human health. Despite their low envi...

Inconsistency of AI in intracranial aneurysm detection with varying dose and image reconstruction.

Scanner-related changes in data quality are common in medical imaging, yet monitoring their impact on diagnostic AI performance remains challenging. I...

"Calming the nightmares": A qualitative study of a socially assistive robot for sensory and emotional support in individuals with eating disorders and PTSD.

Individuals with eating disorders (ED) and co-occurring post-traumatic stress disorder (PTSD) often face difficulties with sensory overload and emotio...

Machine Learning Based Quantitative Structure-Dissolution Profile Relationship.

Determining accurate drug dissolution processes in the gastrointestinal tract is critical in drug discovery as dissolution profiles provide essential ...