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Deep-learning based detection of vessel occlusions on CT-angiography in patients with suspected acute ischemic stroke.

Swift diagnosis and treatment play a decisive role in the clinical outcome of patients with acute ischemic stroke (AIS), and computer-aided diagnosis (CAD) systems can accelerate the underlying diagnostic processes. Here, we developed an artificial neural network (ANN) which allows automated detection of abnormal vessel findings without any a-priori restrictions and in <2 minutes. Pseudo-prospecti...

Aug 15 2023 37582829

FGFR1Pred: an artificial intelligence-based model for predicting fibroblast growth factor receptor 1 inhibitor.

Fibroblast growth factor receptors (FGFRs) are a family of cell surface receptors that bind to fibroblast growth factor (FGF) and mediate various cellular functions (translocating proteins, tissue repair, cell proliferation, development, and differentiation) through complex signaling pathways. The FGFR1 growth receptor is essential in the pathogenesis of numerous malignancies, including but not li...

Aug 11 2023 37566198
Value Proposition of FDA-Approved Artificial Intelligence Algorithms for Neuroimaging.

PURPOSE: The number of FDA-cleared artificial intelligence (AI) algorithms for neuroimaging has grown in the past decade. The adoption of these algori...

Aug 11 2023 37574094
Robotic Surgery in Urology: History from PROBOT to HUGO.

The advent of robotic surgical systems had a significant impact on every surgical area, especially urology, gynecology, and general and cardiac surger...

Aug 11 2023 37631641
New drugs and stock market: a machine learning framework for predicting pharma market reaction to clinical trial announcements.

Pharmaceutical companies operate in a strictly regulated and highly risky environment in which a single slip can lead to serious financial implication...

Aug 7 2023 37550410
One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities.

Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cor...

Jul 28 2023 37503685
AndroPred: an artificial intelligence-based model for predicting androgen receptor inhibitors.

Androgen receptor (AR), a steroid receptor, plays a pivotal role in the pathogenesis of prostate cancer (PCa). AR controls the transcription of genes ...

Jul 26 2023 37493402
Classifying Free Texts Into Predefined Sections Using AI in Regulatory Documents: A Case Study with Drug Labeling Documents.

The US Food and Drug Administration (FDA) regulatory process often involves several reviewers who focus on sets of information related to their respec...

Jul 24 2023 37487037
Exploring the potential of FDA approved anti-diabetic drugs for repurposing against COVID-19: a core combination of multiple computational strategies and integrated artificial intelligence.

The latest variant of coronavirus is omicron. The World Health Organization (WHO) designated variation 'B.1.1.529' named omicron as a variant of conce...

Jul 16 2023 37455488
Establishment of a successful robotic pediatric general surgery practice.

Robotic-assisted surgery (RAS) has a variety of theoretical advantages, including tremor filtration, optimal visualization, and improvement of surgeon...

Jul 15 2023 37452975
Whole Slide Imaging Technology and Its Applications: Current and Emerging Perspectives.

. Whole slide imaging (WSI) represents a paradigm shift in pathology, serving as a necessary first step for a wide array of digital tools to enter the...

Jul 12 2023 37437093
A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism.

The recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a severe t...

Jul 12 2023 37467664
Initial Testing of Robotic Exoskeleton Hand Device for Stroke Rehabilitation.

The preliminary test results of a novel robotic hand rehabilitation device aimed at treatment for the loss of motor abilities in the fingers and thumb...

Jul 12 2023 37514633
Artificial intelligence and cheminformatics tools: a contribution to the drug development and chemical science.

In the ever-evolving field of drug discovery, the integration of Artificial Intelligence (AI) and Machine Learning (ML) with cheminformatics has prove...

Jul 11 2023 37434311
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis.

Intestinal fibrosis, often caused by inflammatory bowel disease, can lead to intestinal stenosis and obstruction, but there are no approved treatments...

Jul 11 2023 37437569
Deep learning in neuroimaging of epilepsy.

In recent years, artificial intelligence, particularly deep learning (DL), has demonstrated utility in diverse areas of medicine. DL uses neural netwo...

Jul 6 2023 37473486
Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval.

INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological pr...

Jul 6 2023 37364225
Marketing and US Food and Drug Administration Clearance of Artificial Intelligence and Machine Learning Enabled Software in and as Medical Devices: A Systematic Review.

IMPORTANCE: The marketing of health care devices enabled for use with artificial intelligence (AI) or machine learning (ML) is regulated in the US by ...

Jul 3 2023 37405771
DeepdlncUD: Predicting regulation types of small molecule inhibitors on modulating lncRNA expression by deep learning.

Targeting lncRNAs by small molecules (SM-lncR) to alter their expression levels has emerged as an important therapeutic modality for disease treatment...

Jul 1 2023 37450966
An FDA Guide on Indications for Use and Device Reporting of Artificial Intelligence-Enabled Devices: Significance for Pediatric Use.

Radiology has been a pioneer in adopting artificial intelligence (AI)-enabled devices into the clinic. However, initial clinical experience has identi...

Jul 1 2023 37400046
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