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Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique.

A rapid and selective LC-MS/MS method is described for the simultaneous assay of Avanafil and Dapoxetine in human plasma a protein precipitation (PP) sample preparation technique. Tadalafil was chosen as the internal standard reaching good recovery and reproducibility while diminishing the effects of the matrix. An Agilent Zorbax Eclipse XDB C column (4.6 × 50 mm, 1.8 μm) was used for the chromat...

Sep 6 2021 35479534

Relation extraction from DailyMed structured product labels by optimally combining crowd, experts and machines.

The effectiveness of machine learning models to provide accurate and consistent results in drug discovery and clinical decision support is strongly dependent on the quality of the data used. However, substantive amounts of open data that drive drug discovery suffer from a number of issues including inconsistent representation, inaccurate reporting, and incomplete context. For example, databases of...

Sep 1 2021 34481057
Visual Servoing Pushing Control of the Soft Robot with Active Pushing Force Regulation.

Soft robots characterize operational safety due to inherent compliance from their soft mechanism, whereas their mechanism enhances the difficulty in a...

Aug 31 2021 34468220
Analysis of docosanol using GC/MS: Method development, validation, and application to human skin permeation studies.

Docosanol is the only US Food and Drug Administration (FDA) approved over-the-counter topical product for treating recurrent oral-facial herpes simple...

Aug 29 2021 35582396
Malfunction Events in the US FDA MAUDE Database: How Does Robotic Gynecologic Surgery Compare with Other Specialties?

STUDY OBJECTIVE: To review malfunction events (MEs) related to the use of the da Vinci robot reported to the United States Food and Drug Administratio...

Aug 28 2021 34464761
Raptor: A Design of a Drain Inspection Robot.

Frequent inspections are essential for drains to maintain proper function to ensure public health and safety. Robots have been developed to aid the dr...

Aug 26 2021 34502633
Intuitive Spatial Tactile Feedback for Better Awareness about Robot Trajectory during Human-Robot Collaboration.

In this work, we extend the previously proposed approach of improving mutual perception during human-robot collaboration by communicating the robot's ...

Aug 26 2021 34502639
A Novel Approach to Automated 3D Spalling Defects Inspection in Railway Tunnel Linings Using Laser Intensity and Depth Information.

The detection of concrete spalling is critical for tunnel inspectors to assess structural risks and guarantee the daily operation of the railway tunne...

Aug 25 2021 34502618
Near-Infrared Artificial Synapses for Artificial Sensory Neuron System.

The computing based on artificial neuron network is expected to break through the von Neumann bottleneck of traditional computer, and to greatly impro...

Aug 21 2021 34418276
Automated Flood Depth Estimates from Online Traffic Sign Images: Explorations of a Convolutional Neural Network-Based Method.

Flood depth monitoring is crucial for flood warning systems and damage control, especially in the event of an urban flood. Existing gauge station data...

Aug 20 2021 34451056
Efficient bipedal locomotion on rough terrain via compliant ankle actuation with energy regulation.

Legged locomotion enables robotic platforms to traverse on rough terrain, which is quite challenging for other locomotion types, such as in wheeled an...

Aug 12 2021 34256362
Machine learning using clinical data at baseline predicts the efficacy of vedolizumab at week 22 in patients with ulcerative colitis.

Predicting the response of patients with ulcerative colitis (UC) to a biologic such as vedolizumab (VDZ) before administration is an unmet need for op...

Aug 12 2021 34385588
Sequence Ontology terminology for gene regulation.

The Sequence Ontology (SO) is a structured, controlled vocabulary that provides terms and definitions for genomic annotation. The Gene Regulation Ense...

Aug 11 2021 34389511
An online, non-destructive method for simultaneously detecting chemical, biological, and physical properties of herbal injections using hyperspectral imaging with artificial intelligence.

Botanical drugs hold great potential to prevent and treat complex diseases. Quality control is essential in ensuring the safety, efficacy, and therape...

Aug 6 2021 34391991
AI Enabled IoRT Framework for Rodent Activity Monitoring in a False Ceiling Environment.

Routine rodent inspection is essential to curbing rat-borne diseases and infrastructure damages within the built environment. Rodents find false ceili...

Aug 6 2021 34450767
Falcon: A False Ceiling Inspection Robot.

Frequent inspections are essential for false ceilings to maintain the service infrastructures, such as mechanical, electrical, and plumbing, and the s...

Aug 5 2021 34450723
Towards an Optimal Footprint Based Area Coverage Strategy for a False-Ceiling Inspection Robot.

False-ceiling inspection is a critical factor in pest-control management within a built infrastructure. Conventionally, the false-ceiling inspection i...

Jul 30 2021 34372408
Ensuring Adequate Development and Appropriate Use of Artificial Intelligence in Pediatric Medical Imaging.

Of over 100 FDA-cleared artificial intelligence (AI) tools for triage, detection, or diagnosis in medical imaging, only one is cleared for use in chil...

Jul 28 2021 34319165
Product Inspection Methodology via Deep Learning: An Overview.

In this study, we present a framework for product quality inspection based on deep learning techniques. First, we categorize several deep learning mod...

Jul 25 2021 34372276
Machine learning to analyze single-case graphs: A comparison to visual inspection.

Behavior analysts commonly use visual inspection to analyze single-case graphs, but studies on its reliability have produced mixed results. To examine...

Jul 15 2021 34263923
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