Latest AI and machine learning research in fda general for healthcare professionals.
Drug repositioning, or the identification of new indications for approved therapeutic drugs, has gained substantial traction with both academics and pharmaceutical companies because it reduces the cost and duration of the drug development pipeline and the likelihood of unforeseen adverse events. To date there has not been a systematic effort to identify such opportunities, in part because of the l...
Synthetic biological circuits are promising tools for developing sophisticated systems for medical, industrial, and environmental applications. So far, circuit implementations commonly rely on gene expression regulation for information processing using digital logic. Here, we present a different approach for biological computation through metabolic circuits designed by computer-aided tools, implem...
BACKGROUND: Sex and age have long been known to affect the ECG. Several biologic variables and anatomic factors may contribute to sex and age-related ...
Controlling the expression of genes is one of the key challenges of synthetic biology. Until recently fine-tuned control has been out of reach, partic...
In the past decade, advances in precision oncology have resulted in an increased demand for predictive assays that enable the selection and stratifica...
With the advances in different biological networks including gene regulation, gene co-expression, protein-protein interaction networks, and advanced a...
A preventive measure for debonding has not been established and is highly desirable to improve the survival rate of computer-aided design/computer-aid...
Identifying drug-drug interactions (DDIs) is a critical enabler for reducing adverse drug events and improving patient safety. Generating proper DDI a...
IMPORTANCE: Following recent US Food and Drug Administration approval, adoption of whole slide imaging in clinical settings may be imminent, and diagn...
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on...
The human carboxylesterase 1 (CES1), responsible for the biotransformation of many diverse therapeutic agents, may contribute to the occurrence of adv...
The use of artificial intelligence will transform clinical practice over the next decade and the early impact of this will likely be the integration o...
Generic drug products are approved by the US Food and Drug Administration (FDA) through Abbreviated New Drug Applications (ANDAs). The ANDA review and...
Although extensive attention has been focused on the enormous potential of artificial intelligence (AI) technology, a major question remains: how sho...
Advances in machine learning in medical imaging are occurring at a rapid pace in research laboratories both at academic institutions and in industry. ...
Psychological sciences have identified a wealth of cognitive processes and behavioral phenomena, yet struggle to produce cumulative knowledge. Progres...
BACKGROUND: Transcription factors (TFs) play important roles in the regulation of gene expression. They can activate or block transcription of downstr...
GPCRs constitute the largest druggable family having targets for 475 Food and Drug Administration (FDA) approved drugs. As GPCRs are of great interest...
The increasingly realistic prospect of artificial intelligence (AI) playing an important role in radiology has been welcomed with a mixture of enthusi...
Acute patient treatment can heavily profit from AI-based assistive and decision support systems, in terms of improved patient outcome as well as incre...