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Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system

While neutralizing ability has traditionally been considered the most important antibody function, a...

A deep learning model captures position-specific effects of plant regulatory sequences and suggests genes under complex regulation

Deep neural networks can be trained to predict gene expression directly from genomic sequence, there...

From bench assays to bedside: a context-embedding transformer predicts monoclonal antibody viscosity, clearance, and regulatory success

Late-stage failures of monoclonal antibody (mAb) programs often reflect developability liabilities, ...

A PLM-Based Method for Predicting Protein Ion Channel Modulators for Drug Discovery and Safety Evaluation

Ion channels are central to regulating neuronal communication, cardiac rhythm, and muscle contractio...

Using Large Language Models to Assemble, Audit, and Prioritize the Therapeutic Landscape

We present an AI-assisted pipeline for disease-specific drug landscape analysis. Given a disease nam...

RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies

Single-cell RNA sequencing (scRNA-seq) enables high-resolution profiling of cellular diversity, but ...

TSProm: Deciphering the Genomic Context of Tissue Specificity

Characterizing tissue-specific (TSp) gene expression is crucial for understanding development and di...

Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

Programmable control of gene expression in specific cell types is essential for both basic discovery...

Integrative metabolome-genome analysis reveals the genetic architecture of metabolic diversity in sorghum grain

Cereal grains are fundamental to global food security and bioenergy production, yet the genetic and ...

AI regulation in healthcare around the world: what is the status quo?

The rapid adoption of artificial intelligence (AI) raises challenges related to ethics, safety, equi...

How AI is used in FDA-authorized medical devices: a taxonomy across 1,016 authorizations

The recent proliferation of AI-enabled medical devices and the growing emphasis on clinical translat...

Synthesizing evidence regarding artificial intelligence generated radiological reports based on medical images: a scoping review protocol

Considering numerous radiological images and the heavy workload of writing corresponding reports in ...

Transport-based transfer learning on Electronic Health Records: Application to detection of treatment disparities

Electronic Health Records (EHRs) sampled from different populations can introduce unwanted bi-ases, ...

Evaluating the Reporting Quality of 21,041 Randomized Controlled Trial Articles

Incomplete reporting of a study’s methods and results hinders efforts to evaluate and reproduce rese...

PED-X-Bench: A Benchmark of Adult-to-Pediatric Extrapolation Decisions in FDA Drug Labels

Pediatric trials are ethically and logistically difficult, so the U.S. FDA often extrapolates adult ...

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