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Development and validation of diagnostic and prognostic prediction tools for dental caries in young children: A protocol

Dental caries is the most common oral disease worldwide, affecting up to 90% of children globally. I...

Assessing the Potential of AI-Driven Drug Repurposing in Ophthalmology: An Analysis of ChatGPT’s Therapeutic Recommendations

This study aimed to evaluate the novelty and potential value of therapeutic suggestions made by an a...

Evaluation of Large Language Models in Medical Examinations: A Scoping Review Protocol

Large language models (LLMs) demonstrate human-level performance in three key domains: linguistic un...

Evaluation and Application of a Probability of Success (POS) Framework in Oncology Trials

Oncology drug development encounters considerable challenges due to positive Phase I trials rarely l...

Quantifying new threats to health and biomedical literature integrity from rapidly scaled publications and problematic research

The last three years have seen an explosion in published manuscripts analysing open-access health da...

Implementing a context-augmented large language model to guide precision cancer medicine

The rapid expansion of molecularly informed therapies in oncology, coupled with evolving regulatory ...

Evaluating the accuracy and consistency of ChatGPT for the management of type 2 diabetes: A cross-sectional study

Large language models (LLMs) have fundamentally changed how patients and clinicians retrieve informa...

A scoping review of the application of artificial intelligence for the analysis of adverse drug events in clinical research

The early detection of adverse drug events (ADEs) became a critical issue in clinical research after...

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk

Understanding how genetic variation influences gene regulation at the single-cell level is crucial f...

AI-GUIDED ENDPOINT SELECTION FOR NEUROPROTECTION TRIALS IN GLAUCOMA

Standard Automated Perimetry (SAP) is the mainstay for monitoring glaucoma progression and has been ...

Bridging Computational and Clinical Strategies to Improve Presurgical Identification of Epileptogenic Networks

About one third of epilepsy patients are drug-resistant. Resective surgery remains a key treatment o...

Association between zidovudine and adverse pregnancy outcomes/congenital malformations: A pharmacovigilance study using FAERS data

Zidovudine (AZT), a key antiretroviral drug used for HIV treatment and preventing mother-to-child tr...

Regulating Flexibility for Artificial Intelligence FDA Experience with Predetermined Change Control Plans

Predetermined Change Control Plans (PCCPs) are a recent regulatory innovation by the U.S. Food and D...

Machine Learning-Based Reconstruction of 2D MRI for Quantitative Morphometry in Epilepsy

Structural neuroimaging analyses require ‘research quality’ images, acquired with costly MRI acquisi...

Serum metabolic signatures are associated with anti-drug antibody development in rheumatoid arthritis patients treated with adalimumab

Development of anti-drug antibodies (ADAs) is a barrier to long-term efficacy of biologic therapies ...

Signal Mining and Analysis of Adverse Events of Isotretinoin: 20-year real-world pharmacovigilance analysis based on the FAERS database

To identify post-marketing adverse event (AE) signals associated with isotretinoin using real-world ...

Epigenetic patient stratification reveals a sub-endotype of type 2 asthma with altered B-cell response

Despite biomarker-guided treatment strategies, clinical outcomes among patients with type 2 (T2)-hig...

A Systematic Process for Assessing Fitness-for-Purpose of Health Outcomes for Computable Phenotyping with Electronic Health Record Data

Information from electronic health records (EHRs) may be incorporated into computable phenotype algo...

A randomized clinical trial reveals effects of mindfulness and slow breathing on plasma amyloid beta levels

Prior research suggests that meditation may slow brain aging and reduce the risk of Alzheimer’s dise...

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