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eRFSVM: a hybrid classifier to predict enhancers-integrating random forests with support vector machines.

BACKGROUND: Enhancers are tissue specific distal regulation elements, playing vital roles in gene regulation and expression. The prediction and identification of enhancers are important but challenging issues for bioinformatics studies. Existing computational methods, mostly single classifiers, can only predict the transcriptional coactivator EP300 based enhancers and show low generalization perfo...

Jun 30 2016 28096768

Dynamic regulation of RNA editing in human brain development and disease.

RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical development: stable high, stable low and increasing. RNA secondary structure and the temporal expression of adenosine deaminase acti...

Jun 27 2016 27348216
Application of the removal of pollutants from textile industry wastewater in constructed wetlands using fuzzy logic.

There are more than a hundred textile industries in Turkey that discharge large quantities of dye-rich wastewater, resulting in water pollution. Such ...

Jun 24 2016 27258097
A new algorithmic approach for the extraction of temporal associations from clinical narratives with an application to medical product safety surveillance reports.

The sheer volume of textual information that needs to be reviewed and analyzed in many clinical settings requires the automated retrieval of key clini...

Jun 17 2016 27327528
tarSVM: Improving the accuracy of variant calls derived from microfluidic PCR-based targeted next generation sequencing using a support vector machine.

BACKGROUND: Targeted sequencing of discrete gene sets is a cost effective strategy to screen subjects for monogenic forms of disease. One method to ac...

Jun 10 2016 27287006
An Application of Self-Organizing Map for Multirobot Multigoal Path Planning with Minmax Objective.

In this paper, Self-Organizing Map (SOM) for the Multiple Traveling Salesman Problem (MTSP) with minmax objective is applied to the robotic problem of...

Jun 2 2016 27340395
An Imbalanced Learning based MDR-TB Early Warning System.

As a man-made disease, multidrug-resistant tuberculosis (MDR-TB) is mainly caused by improper treatment programs and poor patient supervision, most of...

May 21 2016 27209184
Adverse Events in Robotic Surgery: A Retrospective Study of 14 Years of FDA Data.

BACKGROUND: Use of robotic systems for minimally invasive surgery has rapidly increased during the last decade. Understanding the causes of adverse ev...

Apr 20 2016 27097160
SMARTbot: A Behavioral Analysis Framework Augmented with Machine Learning to Identify Mobile Botnet Applications.

Botnet phenomenon in smartphones is evolving with the proliferation in mobile phone technologies after leaving imperative impact on personal computers...

Mar 15 2016 26978523
Vaccine and Drug Ontology Studies (VDOS 2014).

The "Vaccine and Drug Ontology Studies" (VDOS) international workshop series focuses on vaccine- and drug-related ontology modeling and applications. ...

Feb 25 2016 26918107
Merge Fuzzy Visual Servoing and GPS-Based Planning to Obtain a Proper Navigation Behavior for a Small Crop-Inspection Robot.

The concept of precision agriculture, which proposes farming management adapted to crop variability, has emerged in recent years. To effectively imple...

Feb 24 2016 26927102
Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.

Understanding telomere length maintenance mechanisms is central in cancer biology as their dysregulation is one of the hallmarks for immortalization o...

Feb 22 2016 26908654
A Simple fMRI Compatible Robotic Stimulator to Study the Neural Mechanisms of Touch and Pain.

This paper presents a simple device for the investigation of the human somatosensory system with functional magnetic imaging (fMRI). PC-controlled pne...

Feb 1 2016 26833039
A knowledgebase of the human Alu repetitive elements.

Alu elements are the most abundant retrotransposons in the human genome with more than one million copies. Alu repeats have been reported to participa...

Jan 28 2016 26827622
Analytical Determination of Vitamin B12 Content in Infant and Toddler Milk Formulas by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).

The development of a sample preparation method and optimization of the analytical instrumentation conditions were performed for the determination of t...

Dec 31 2015 26877636
Challenges in circulating tumor cell detection by the CellSearch system.

Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large b...

Dec 25 2015 26795350
Serial change of C1 inhibitor in patients with sepsis--a preliminary report.

OBJECTIVE: C1 inhibitor (C1INH) regulates not only the complement system but also the plasma kallikrein-kinin, fibrinolytic, and coagulation systems. ...

Dec 19 2015 26782794
Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma.

A quantitative method for clopidogrel using online-SPE tandem LC-MS/MS was developed and fully validated according to the well-established FDA guideli...

Dec 15 2015 26904399
Development and Validation of Simple RP-HPLC Method for Intracellular Determination of Fluconazole Concentration and Its Application to the Study of Candida albicans Azole Resistance.

Candida albicans (strains NCTC-885-653 and ATCC-10231) long-term cultivated in the presence of antifungal agent fluconazole (FLC) and classical microb...

Dec 9 2015 26783393
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