Gastroenterology

Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease.

INTRODUCTION: Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). This study aims to investigate how microbial and metabolic alterations contribute to disease development and assess whether biomarkers identified in one d...

Technology advances in the placement of naso-enteral tubes and in the management of enteral feeding in critically ill patients: A narrative study.

Enteral feeding needs secure access to the upper gastrointestinal tract, an evaluation of the gastric function to detect gastrointestinal intolerance, and a nutritional target to reach the patient's needs. Only in the last decades has progress been accomplished in techniques allowing an appropriate placement of the nasogastric tube, mainly reducing pulmonary complications. These techniques include...

Evaluation of tumour pseudocapsule using computed tomography-based radiomics in pancreatic neuroendocrine tumours to predict prognosis and guide surgical strategy: a cohort study.

BACKGROUND: To date, indications for a surgical approach of small pancreatic neuroendocrine tumours (PanNETs) remain controversial. This cohort study ...

MRI Radiomics to Predict Early Treatment Response to TACE Combined with Lenvatinib Plus a PD-1 Inhibitor for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus.

PURPOSE: To develop and validate a predictor for early treatment response in hepatocellular carcinoma (HCC) patients accompanied by portal vein tumor ...

The future of critical care: AI-powered mortality prediction for acute variceal gastrointestinal bleeding and acute non-variceal gastrointestinal bleeding patients.

BACKGROUND: Acute upper gastrointestinal bleeding (AUGIB) is one of the most common critical diseases encountered in the intensive care unit (ICU), wi...

Predicting Immunotherapy Response in Unresectable Hepatocellular Carcinoma: A Comparative Study of Large Language Models and Human Experts.

Hepatocellular carcinoma (HCC) is an aggressive cancer with limited biomarkers for predicting immunotherapy response. Recent advancements in large lan...

Integrating Network Analysis and Machine Learning to Elucidate Chemical-Induced Pancreatic Toxicity in Zebrafish Embryos.

Zebrafish (Danio rerio) are a popular vertebrate model for high-throughput toxicity testing, serving as a model for embryonic development and disease ...

Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.

Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. M...

SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome viru...

Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.

Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanopart...

AutoFRS: an externally validated, annotation-free approach to computational preoperative complication risk stratification in pancreatic surgery - an experimental study.

BACKGROUND: The risk of postoperative pancreatic fistula (POPF), one of the most dreaded complications after pancreatic surgery, can be predicted from...

Cytotoxicity and Antiparasitic Effects of Toltrazuril Against Enteromyxum leei in Olive Flounders: In Vitro and In Vivo Analyses.

The parasite Enteromyxum leei causes serious emaciation disease in marine fish species. Toltrazuril exhibits antiparasitic effects; however, the simul...

Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma.

OBJECTIVE: The detection kit for plasma Chitinase-3-like Protein 1 was developed using the magnetic bead chemiluminescence method, in order to investi...

AI-Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu-Tenesmus.

Defecation, a fundamental physiological process, remains underexplored despite its importance in human health. To address this gap, a smart toilet sys...

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib.

Fruquintinib (FRUZAQLA) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (-1, -2, and -3). Tw...

Modified albumin-bilirubin grade and alpha-fetoprotein score for predicting prognosis of hepatocellular carcinoma patients undergoing conventional transarterial chemoembolization.

BACKGROUND: Predicting post-treatment prognosis in hepatocellular carcinoma (HCC) patients undergoing conventional transarterial chemoembolization (cT...

Percutaneous Endoscopic Debridement and Drainage as a First-Line Diagnosis and Management Intervention for Spondylodiscitis: A Novel Treatment Algorithm.

BACKGROUND AND OBJECTIVES: Spondylodiscitis (SD) is an infection of the intervertebral disk. In the nonseptic, MRI-positive patient without focal defi...

Pien Tze Huang Attenuates Cell Proliferation and Stemness Promoted by miR-483-5p in Hepatocellular Carcinoma Cells.

OBJECTIVE: To investigate the effect of miR-483-5p on hepatocellular carcinoma (HCC) cells proliferation and stemness, as well as the attenuating effe...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure t...

Comparison of short- and long-term outcomes for robotic versus laparoscopic gastrectomy in elderly patients with gastric cancer: a multicenter cohort study.

BACKGROUND: There is limited evidence from large-scale multicenter studies regarding the short- and long-term efficacy of robotic gastrectomy (RG) in ...