Gastroenterology

Bisphenol A promotes esophageal carcinogenesis by activating the MMP1-PCOLCE regulatory axis and remodeling the tumor immune microenvironment.

Bisphenol A (BPA), a ubiquitous environmental endocrine-disrupting chemical extensively used in plastic products, has been increasingly recognized for its carcinogenic potential. However, the molecular mechanisms underlying BPA-associated esophageal carcinogenesis remain incompletely understood. In this study, we integrated transcriptomic differential expression profiling, weighted gene co-express...

The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial.

PURPOSE: To evaluate the effects of a plant-based milk with fermented brown rice on constipation symptoms in patients with functional constipation and to identify post-intervention gut microbial alterations that may underlie potential mechanisms. METHODS: This is a randomized controlled trial among 100 participants with functional constipation. Participants were randomly assigned to the interventi...

Artificial intelligence and multi-omics revealed the authentic regulation of ADP-ribosylation in modulation Treg/Th17 ecosystem and multi-target therapeutic strategy enrichment for HBV+ Hepatocellular Carcinoma patients.

OBJECTIVE: Dysregulation of Protein post-translation(PTM) and Treg/Th17 balance contribute to the progression of Hepatocellular Carcinoma(HCC) patient...

Aspartame drives the continuous progression from MASLD to HCC.

BACKGROUND: Aspartame (APM), a widely used sweetener, has been linked to cancers, yet its molecular impact on metabolic dysfunction-associated steatot...

Magnetic Resonance Spectroscopy Deep Learning with Magnetic Resonance Background Generator Enables In Vivo Metabolite Quantification of Hepatic Encephalopathy.

OBJECTIVE: Short-TE Proton Magnetic Resonance Spectroscopy (SPMRS) allows non-invasive, radiation-free detection of biomolecules including key brain m...

Explainable machine learning identifies small high-performance gene signatures from full transcriptomes in human liver preservation cohorts.

Transcriptomic studies of liver preservation and ischemia-reperfusion injury (IRI) often report large gene lists that are difficult to translate into ...

Benchmarking docking and ML re-scoring screening performance for KRAS G12D in pancreatic cancer.

The KRAS G12D mutation is commonly found in pancreatic cancer and is integral to the cell signaling pathway, making it a critical target for drug deve...

Comparative diagnostic accuracy of image-enhanced endoscopy modalities and artificial intelligence-assisted endoscopy for gastric intestinal metaplasia and gastric dysplasia: protocol for a systematic review and diagnostic test network meta-analysis.

INTRODUCTION: Gastric intestinal metaplasia (GIM) and gastric dysplasia are critical precursors in the Correa cascade of gastric carcinogenesis. Altho...

Unsupervised Machine Learning of Inflammatory Bowel Disease Case Reports Reveals Decades of Evolving Research Themes.

BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) case reports provide rich longitudinal insights but have rarely been analyzed using quantitative...

Pharmacogenomic characterization of a uric acid metabolism-related signature associated with prognosis and drug sensitivity in gastric cancer.

Gastric cancer (GC) remains a major cause of cancer-related mortality worldwide. Increasing evidence suggests that metabolic reprogramming contributes...

Elucidating the pathway activity and prognostic significance of diverse regulatory cell death patterns in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a five-year survival rate below 10%. Regulatory cell death (RCD) plays ...

TACE-induced liver injury in hepatocellular carcinoma: mechanisms, prediction, and prevention in the era of gut microbiota and inflammasome research.

Transarterial chemoembolization (TACE) is a cornerstone locoregional therapy for hepatocellular carcinoma (HCC), yet most candidates also have cirrhos...

White cell - platelet ratio: A strong indicator for early mortality in liver cirrhosis patients with esophagogastric varices.

Esophagogastric varices (EGV) in liver cirrhosis patients within the intensive care unit (ICU) is a significant medical concern. This study aims to de...

Multi-cohort integration and machine learning identify CPVL as a novel oncogenic driver in gastric cancer.

BACKGROUND: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, and the prognosis of advanced GC remains poor. Systemat...

A dual-contrast deep learning model for automated assessment of sarcopenia using MRI.

PURPOSE: To develop a dual-contrast deep-learning model for automated muscle segmentation on spin-echo and Dixon magnetic resonance imaging (MRI) for ...

The Addition of Computer-Aided Detection (CADe) to Texture and Color Enhancement Imaging (TXI) Does Not Improve Adenoma Detection Rate During Colonoscopy: A Prospective Study.

OBJECTIVES: Early detection and resection of colorectal polyps prevent their progression toward advanced adenocarcinomas. The use of Texture and Color...

Integrative analysis of machine learning and single-cell sequencing identifies IGHG1 as a therapeutic target for epimedium in diabetes-gastric cancer comorbidity.

BACKGROUND: The clinical comorbidity of diabetes mellitus (DM) and gastric cancer (GC) presents a significant healthcare challenge, as these two condi...

Radiation scatter at fluoroscopy-guided endoscopic procedures: Building towards further optimization.

INTRODUCTION: Exposure to ionizing radiation by endoscopy personnel during fluoroscopy-guided procedures remains a health hazard. We aimed to evaluate...

A Physics-Informed Deep Learning Framework for Estimating Muscle Activation Patterns Following Achilles Tendon Repair.

Accurate soleus (SOL) activation assessment is essential for Achilles tendon rupture (ATR) recovery, yet direct measurement remains a clinical challen...

Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer.

BACKGROUND: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain lar...