Gastroenterology

Clinical utility beyond detection rates: Interpreting artificial intelligence in FIT-positive colonoscopy.

Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review).

Critical illness induces a marked disruption of the gut‑brain axis, which is characterized by systemic inflammation and the rapid collapse of intestinal barrier integrity. These pathological shifts facilitate the translocation of pathogen‑associated molecular patterns, thereby driving neuroinflammation and exacerbating intensive care unit‑acquired syndromes such as delirium and muscular wasting. A...

Serum-Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity-Linked Signatures.

INTRODUCTION: Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by complex pathogenesis, variable clinical phenotypes, and b...

Gut Microbiota and Inflammatory Diseases: Emerging Insights and Therapeutic Perspectives. A Report From the Spanish Inflammatory Diseases Network.

The gut microbiota constitutes a highly complex ecosystem that plays a pivotal role in maintaining human health and modulating the immune response. Dy...

E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8+ T Cell Dysfunction in Gastric Cancer Through Degradation of SST.

AIM: To figure out the role and molecular mechanism of SST in the progression of GC. METHODS: GC microarray data GSE118916 were downloaded from the GE...

Personalized prediction of local control after stereotactic radiosurgery for craniopharyngioma: a multicenter machine learning survival model.

BACKGROUND: Stereotactic radiosurgery (SRS) is used in selected patients with craniopharyngioma, yet counseling and follow-up planning often rely on p...

Deep learning-based detection of acute pancreatitis on abdominal contrast-enhanced CT.

OBJECTIVE: We developed and evaluated a deep learning (DL) model for image-based detection of acute pancreatitis (AP) on abdominal contrast-enhanced C...

Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a 5-year survival rate of only 13%. Despite recent advances in diagnosi...

Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women.

BACKGROUND: Understanding how skeletal muscle responds to weight loss is crucial for developing targeted strategies to manage obesity and promote sust...

AI-driven discovery and validation of a GIPC1 PDZ domain inhibitor for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) remains highly aggressive, with a five-year survival rate under 13.3%, due to late diagnosis, rapid progressio...

Mechanisms, management and prevention of anorectal sexually transmitted infections.

Anorectal bacterial sexually transmitted infections, predominantly chlamydia, gonorrhoea and syphilis, represent a substantial and evolving global hea...

Identifying the Most Important Influencing Factors Based on Demographic Information, Nutrition, Physical Activity, Leisure Time, and Underlying Diseases in the Severity of Disease in COVID-19 Patients Using Data Mining Techniques.

BACKGROUND AND AIMS: The COVID-19 pandemic has affected millions of individuals worldwide and resulted in substantial mortality. Data mining and machi...

LSI-Age: A machine learning derived liver-related immune clock for hepatocellular carcinoma risk.

Automated readings of imaging reports by natural language processing (NLP) supplemented by clinical data predict disease course in children and adults with Crohn's disease: report from the epi-IIRN.

INTRODUCTION: The implementation of imaging features in administrative databases and electronic health records is limited by non-standardized free-tex...

Epigallocatechin gallate inhibits high-fat/choline diet-induced trimethylamine production via regulation of intestinal Serratia and Lactobacillus communities.

High-fat/choline diets can induce the production of the enterogenous metabolite trimethylamine-N-oxide (TMAO). TMAO is synthesized from its precursor ...

Three-class radiomic differentiation of hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma on multiphasic contrast-enhanced CT.

PURPOSE: Preoperative differentiation of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular-cholangioc...

Enterococcus faecium MMX derived from traditional fermented mare's milk alleviates colitis by modulating the LCN2-NLRP3 pyroptosis axis.

Ulcerative colitis (UC) is a relapsing inflammatory disorder of the intestine for which safe and effective therapeutic strategies are urgently needed....

Methodological Considerations on Central Pathology Review in Artificial Intelligence-Assisted Gastric Neoplasm Detection.

Reply to "Methodological Considerations on Central Pathology Review in Artificial Intelligence-Assisted Gastric Neoplasm Detection".

Machine Learning Clustering Identifies Achalasia-Spectrum Phenotypes in Distal Esophageal Spasm.

BACKGROUND/AIMS: : Distal esophageal spasm (DES) is a rare, heterogeneous esophageal motility disorder with variable treatment responses. Machine lear...