Gastroenterology

Author Correction: Machine learning model-guided selective use of temporary diverting ileostomy in rectal cancer surgery: a randomized controlled trial.

Machine learning identifies ac4C-related prognostic signature and TUBA1C as therapeutic target in COAD.

To explore the role of N4-acetylcytidine (ac4C)-related genes (acRGs) in colon adenocarcinoma (COAD) and identify reliable prognostic biomarkers and potential therapeutic targets. Multi-source transcriptomic datasets (TCGA-COAD, GSE39582, GSE17536) and single-cell RNA-seq data were analyzed. Ten machine learning algorithms were integrated to construct an acRG-based prognostic signature (acRGBS). I...

Toward a future role for liver biopsy in HCC: literature evidence and survey-based perspectives from Korean experts.

The role of liver biopsy in hepatocellular carcinoma (HCC) is being re-evaluated in the era of precision oncology and biomarker-driven systemic therap...

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science.

New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human-relevant alternatives to tradi...

PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [68Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.

Lesions with a Prostate Imaging-Reporting and Data System (PI-RADS) score of 4 or greater on multiparametric MRI (mpMRI) indicate a high likelihood of...

Therapeutic hybrid intelligence with neural and knowledge-based expert reasoning for SRS (THINKERS): a mixture-of-experts framework for gastrointestinal brain metastases.

BACKGROUND: Brain metastases from gastrointestinal (GI) malignancies are heterogeneous, while stereotactic radiosurgery dose selection remains guided ...

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer.

IMPORTANCE: Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma ...

Cough Hypersensitivity in Gastroesophageal Reflux-Induced Chronic Cough: Insights from Reflux Monitoring and High-Resolution Manometry.

BACKGROUND: Cough hypersensitivity contributes to the heterogeneity of gastroesophageal reflux-induced chronic cough (GERC), but its associated factor...

From dysbiosis to precision oncology: translational role of the microbiome in gastrointestinal cancer.

Gastrointestinal (GI) cancers, including colorectal, gastric, pancreatic, hepatocellular, and esophageal malignancies, remain a leading cause of cance...

Integrating virtual docking and neural network modeling to predict the anti-inflammatory potential of dietary polyphenols in ulcerative colitis.

While the systemic anti-inflammatory benefits of dietary polyphenols are well-established, the specific activities of structurally diverse polyphenols...

Cost-Effectiveness of AI-Enabled Electrocardiography for Screening MASLD-Associated Advanced Chronic Liver Disease in the US Population.

BACKGROUND: MASLD is the most prevalent chronic liver disease worldwide, with pooled global prevalence estimates of approximately 30%. Current noninva...

Predicting Histotripsy Focal Shifts in the Liver From Acoustic Aberrations Using a Deep Learning Model.

OBJECTIVE: To develop a deep learning model for predicting histotripsy focal shifts in the liver caused by acoustic aberrations for real-time treatmen...

Feasibility of a Stool State Check App Using AI During Bowel Preparation Before Colonoscopy: Multicenter Prospective Study (SCAN Study).

BACKGROUND: Optimal bowel preparation (BP) is crucial for a successful colonoscopy. Although multiple factors influence BP quality, including patient ...

Patient-Derived Organoids for Hepatobiliary Cancers: Molecular Mechanisms, Translational Applications and Precision Therapeutics.

Hepatobiliary cancers are highly heterogeneous malignant tumors, and the drug resistance frequently emerges at advanced stages. Patient-derived organo...

Identification of Primary Sclerosing Cholangitis: ICD-10 Code Validation and Comparison with a Large Language Model Approach.

BACKGROUND: Retrospective studies investigating primary sclerosing cholangitis (PSC) have been limited by the absence of a PSC-specific diagnostic cod...

Integrative Multi-Omics Analysis Identifies Thrombosis-Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer.

Emerging evidence indicates that coagulation-related molecular programs are associated with thrombosis, tumor progression, and molecular dysregulation...

Dedicated Endoscopy for Barrett's Oesophagus With Higher Dysplasia Yield May Reduce Seattle Protocol Biopsies: Results From UK Multicentre Study.

BACKGROUND: Dedicated service for Barrett's oesophagus (BO) surveillance may be more effective than conventional service, according to some single cen...

Identification of Pre-Diagnostic Protein Biomarkers for Liver Cirrhosis Based on Prospective Analysis of a Large-Scale Plasma Proteomics in the UK Biobank.

PURPOSE: Liver fibrosis and cirrhosis represent critical stages in the progression of chronic liver disease, yet their key molecular features remain i...

The therapeutic potential of saponins for neurological diseases via the gut-brain axis.

Neurological diseases (NDs) constitute a significant threat to global health and impose considerable economic burdens on society due to their complex ...

Real-world clinical impact of implementing and updating a deep learning-based automatic contouring system in rectal cancer radiotherapy.

BACKGROUND: Accurate delineation of target volumes and organs-at-risk (OARs) is a critical yet labor-intensive component of rectal cancer radiotherapy...