Gastroenterology

CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.

AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poo...

Integrated Network Analysis Suggests an miR-21/MMP/VEGF-Associated Regulatory Axis in Gastric Cancer.

BACKGROUND, AIMS: Gastric cancer (GC) pathogenesis involves complex molecular interactions that rema...

Evolution of peptide-mediated siRNA delivery - from early design to next generation platform.

Small interfering RNA (siRNA) therapeutics has huge potential for treating many diseases, including ...

Signal Detection and Temporal Analysis of Aromatase Inhibitor-Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief-Propagation Network and Frequentist Metrics.

BACKGROUND: This study assessed the real-world hepatotoxicity of third-generation aromatase inhibito...

HBV-Specific T Cell Responses for Short-Term Hepatitis Progression Prediction: A Comparative, Interpretable Machine Learning Study.

BACKGROUND & AIMS: As central determinants of viral control and immunopathology, hepatitis B virus (...

Machine Learning Predicts Treatment Response and Prognostic Pathways From Whole-Blood Transcriptome in Primary Biliary Cholangitis.

BACKGROUND AND AIMS: Prognostic biomarkers that link disease progression and/or responses to therape...

Building Trustworthy Artificial Intelligence for Gastrointestinal Endoscopy.

CT radiomics for noninvasive prediction of histologic differentiation in gastric cancer.

BACKGROUND: The histological differentiation grade of gastric cancer critically influences treatment...

Clinical utility beyond detection rates: Interpreting artificial intelligence in FIT-positive colonoscopy.

E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8+ T Cell Dysfunction in Gastric Cancer Through Degradation of SST.

AIM: To figure out the role and molecular mechanism of SST in the progression of GC. METHODS: GC mic...

Personalized prediction of local control after stereotactic radiosurgery for craniopharyngioma: a multicenter machine learning survival model.

BACKGROUND: Stereotactic radiosurgery (SRS) is used in selected patients with craniopharyngioma, yet...

Deep learning-based detection of acute pancreatitis on abdominal contrast-enhanced CT.

OBJECTIVE: We developed and evaluated a deep learning (DL) model for image-based detection of acute ...

Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a 5-year survival rat...

Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women.

BACKGROUND: Understanding how skeletal muscle responds to weight loss is crucial for developing targ...

AI-driven discovery and validation of a GIPC1 PDZ domain inhibitor for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) remains highly aggressive, with a five-year survival rate un...

Mechanisms, management and prevention of anorectal sexually transmitted infections.

Anorectal bacterial sexually transmitted infections, predominantly chlamydia, gonorrhoea and syphili...

Identifying the Most Important Influencing Factors Based on Demographic Information, Nutrition, Physical Activity, Leisure Time, and Underlying Diseases in the Severity of Disease in COVID-19 Patients Using Data Mining Techniques.

BACKGROUND AND AIMS: The COVID-19 pandemic has affected millions of individuals worldwide and result...

LSI-Age: A machine learning derived liver-related immune clock for hepatocellular carcinoma risk.

Automated readings of imaging reports by natural language processing (NLP) supplemented by clinical data predict disease course in children and adults with Crohn's disease: report from the epi-IIRN.

INTRODUCTION: The implementation of imaging features in administrative databases and electronic heal...

Epigallocatechin gallate inhibits high-fat/choline diet-induced trimethylamine production via regulation of intestinal Serratia and Lactobacillus communities.

High-fat/choline diets can induce the production of the enterogenous metabolite trimethylamine-N-oxi...

Three-class radiomic differentiation of hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma on multiphasic contrast-enhanced CT.

PURPOSE: Preoperative differentiation of hepatocellular carcinoma (HCC), intrahepatic cholangiocarci...