Gastroenterology

Latest AI and machine learning research in gastroenterology for healthcare professionals.

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Transforming Histology into Virtual Multiplex Immunofluorescence to Decode Prognostic Spatial Immunity in Hepatocellular Carcinoma

The spatial organization of the tumor immune microenvironment (TIME) drives hepatocellular carcinoma (HCC) prognosis but remains unquantifiable on routine H&E slides. Here, we present HCCExplorer, a deep learning framework that translates H&E into virtual multiplex immunofluorescence (mIF) and uses multi-modal graph learning to decode spatial survival signals. Trained on 30 H&E-mIF slide pairs, HC...

CMSA-Net: Causal Multi-scale Aggregation with Adaptive Multi-source Reference for Video Polyp Segmentation

Video polyp segmentation (VPS) is an important task in computer-aided colonoscopy, as it helps doctors accurately locate and track polyps during examinations. However, VPS remains challenging because polyps often look similar to surrounding mucosa, leading to weak semantic discrimination. In addition, large changes in polyp position and scale across video frames make stable and accurate segmentati...

Feb 26 2026 2602.22821v1
ColoDiff: Integrating Dynamic Consistency With Content Awareness for Colonoscopy Video Generation

Colonoscopy video generation delivers dynamic, information-rich data critical for diagnosing intestinal diseases, particularly in data-scarce scenario...

Feb 26 2026 2602.23203v1
EndoDDC: Learning Sparse to Dense Reconstruction for Endoscopic Robotic Navigation via Diffusion Depth Completion

Accurate depth estimation plays a critical role in the navigation of endoscopic surgical robots, forming the foundation for 3D reconstruction and safe...

Feb 25 2026 2602.21893v2
Development and Validation of CPX-MATE: An End-to-End Medical Education Platform Integrating Voice-Based Virtual Patient Simulation and Automated Real-time Evaluation

Background: Objective Structured Clinical Examination (OSCE; Clinical Performance Examination [CPX] in South Korea) is a high-stakes assessment of cli...

VasGuideNet: Vascular Topology-Guided Couinaud Liver Segmentation with Structural Contrastive Loss

Accurate Couinaud liver segmentation is critical for preoperative surgical planning and tumor localization.However, existing methods primarily rely on...

Feb 25 2026 2602.21539v1
Structure-to-Image: Zero-Shot Depth Estimation in Colonoscopy via High-Fidelity Sim-to-Real Adaptation

Monocular depth estimation (MDE) for colonoscopy is hampered by the domain gap between simulated and real-world images. Existing image-to-image transl...

Feb 25 2026 2602.21740v1
EndoDDC: Learning Sparse to Dense Reconstruction for Endoscopic Robotic Navigation via Diffusion Depth Completion

Accurate depth estimation plays a critical role in the navigation of endoscopic surgical robots, forming the foundation for 3D reconstruction and safe...

Feb 25 2026 2602.21893v1
Hepato-LLaVA: An Expert MLLM with Sparse Topo-Pack Attention for Hepatocellular Pathology Analysis on Whole Slide Images

Hepatocellular Carcinoma diagnosis relies heavily on the interpretation of gigapixel Whole Slide Images. However, current computational approaches are...

Feb 23 2026 2602.19424v1
Counterfactual Understanding via Retrieval-aware Multimodal Modeling for Time-to-Event Survival Prediction

This paper tackles the problem of time-to-event counterfactual survival prediction, aiming to optimize individualized survival outcomes in the presenc...

Feb 23 2026 2602.19987v1
Multi-Modal Monocular Endoscopic Depth and Pose Estimation with Edge-Guided Self-Supervision

Monocular depth and pose estimation play an important role in the development of colonoscopy-assisted navigation, as they enable improved screening by...

Feb 19 2026 2602.17785v1
FoundationPose-Initialized 3D-2D Liver Registration for Surgical Augmented Reality

Augmented reality can improve tumor localization in laparoscopic liver surgery. Existing registration pipelines typically depend on organ contours; de...

Feb 19 2026 2602.17517v1
OmniCT: Towards a Unified Slice-Volume LVLM for Comprehensive CT Analysis

Computed Tomography (CT) is one of the most widely used and diagnostically information-dense imaging modalities, covering critical organs such as the ...

Feb 18 2026 2602.16110v1
Quality versus quantity of training datasets for artificial intelligence-based whole liver segmentation

Artificial intelligence (AI) based segmentation has many medical applications but limited curated datasets challenge model training; this study compar...

AI-DRIVEN DIAGNOSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ASSOCIATED COMORBIDITIES

Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent hepatic condition caused by the buildup of fat in the liver. It is frequently associ...

SydneyMTL: Interpretable Multi-Task Learning for Complete Sydney System Assessment in Gastric Biopsies

The Updated Sydney System (USS) provides a standardized framework for grading gastritis and stratifying gastric cancer risk. However, subjective obser...

Multi-Model Clinical Validation of an AI-Powered Biomarker Analysis Framework: A Cross-Vendor Benchmark on 4,018 NHANES Patients

Background: Large language models (LLMs) show promise for clinical decision support, yet most validation studies evaluate single models, leaving quest...

NeRFscopy: Neural Radiance Fields for in-vivo Time-Varying Tissues from Endoscopy

Endoscopy is essential in medical imaging, used for diagnosis, prognosis and treatment. Developing a robust dynamic 3D reconstruction pipeline for end...

Feb 17 2026 2602.15775v1
Biomarker Identification in Pancreatic Cancer Through Concordant Differential Expression and Interpretable Machine Learning Analyses

Background: Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal malignancies of the gastrointestinal tract. The poor prognosis i...

Metagenomics AI powered prediction of Inflammatory Bowel Disease and Probiotic Recommendation

Background and Objective The dysbiosis of human gut microbiome has been increasingly seen to have a relation in the development of autoimmune diseases...

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