Latest AI and machine learning research in genetics for healthcare professionals.
Emerging evidence links reactive oxygen species modulator 1 (ROMO1), a key mitochondrial ROS regulator, to rheumatoid arthritis (RA) pathogenesis. However, its exact mechanism remains elusive given the conflicting evidence about its specific function. We used a four-level integrative framework combining multi-omics data and literature‑supported mechanistic inference. At the genetic level, Mendelia...
OBJECTIVE: This review presents Darwinian nanomedicine as an artificial intelligence (AI)-enabled drug delivery strategy that applies Darwinian evolutionary principles as a computational and engineering analogy. Rather than implying biological evolution of nanoparticles, the framework employs iterative cycles of variation, selection, adaptation, and computational inheritance to optimize nanopartic...
Tomato fruit weight is primarily controlled by stable genetic effects and domestication-/improvement-associated loci, including prominent chromosome 5...
Traumatic brain injury (TBI) induces secondary neuroinflammation driven by oxidative stress, inflammasome activation, and immune remodeling, yet speci...
Small interfering RNA (siRNA) therapeutics have emerged as a transformative approach for sequence-specific gene silencing, offering the potential to t...
Viral diseases pose a serious threat to global public health, agriculture, and biosecurity. Conventional antiviral strategies are often limited by an ...
The relationship between diabetes mellitus and prostate cancer (PC) represents one of the most intriguing paradoxes in cancer epidemiology, with diabe...
Preterm brain injury remains a leading cause of long‑term neurodevelopmental impairment despite advances in neonatal care. Oxidative stress (OS), aris...
New Delhi metallo-β-lactamase-1 (NDM-1), which has emerged globally, exhibits resistance to almost all β-lactam antibiotics, including carbapenems, po...
Quantitative pollen viability analysis is a critical but labor-intensive step in plant reproductive biology. Existing deep-learning Segment Anything M...
BACKGROUND: Human papilloma virus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is rising. Despite the prognostic and therapeu...
COPD is a progressive respiratory disorder characterized by persistent airflow limitation and chronic inflammation, yet the role of N4-acetylcytidine ...
In taxonomic research, traditional phylogenetic tree- and structure-based analyses of genetic data are increasingly complemented by machine-learning-b...
To explore the role of N4-acetylcytidine (ac4C)-related genes (acRGs) in colon adenocarcinoma (COAD) and identify reliable prognostic biomarkers and p...
The role of liver biopsy in hepatocellular carcinoma (HCC) is being re-evaluated in the era of precision oncology and biomarker-driven systemic therap...
PURPOSE OF REVIEW: This review surveys recent advances in artificial intelligence-guided small molecule discovery and gene therapy, with a focus on ge...
How domestication shapes brain evolution remains an open question. In this study, we integrated single-nucleus RNA sequencing (snRNA-seq), population ...
Breast cancer is a highly heterogeneous malignant tumour, whose initiation and progression are closely associated with aberrant rewiring of protein-pr...
IMPORTANCE: Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma ...
IMPORTANCE: Pleomorphic dermal sarcomas (PDSs) are classified as sarcomas; however, they share features with cutaneous carcinomas, such as presentatio...