Genetics

Chemical-scale force responses across G-quadruplex topologies via machine learning.

G-quadruplexes (GQs) are four-stranded DNA structures formed by guanine-rich sequences and can act a...

Addressing the Blind Spots of Deaminase Base Editors with CRISPR-Cas Glycosylase-Based Editors.

The emergence of CRISPR base editors signifies a pivotal shift in genome editing, moving beyond the ...

Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.

Primary immune thrombocytopenia (ITP) is an autoimmune disease, in which B-lymphocytes drive autoant...

Thermal Shifts Dominate Single-Gene Responses to Transcription-Targeting Antibiotics.

Combined exposure to thermal and antibiotic stresses is ubiquitous. How cells adapt to these concurr...

Integrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC.

Ductal carcinoma in situ (DCIS) is a non-invasive precursor of invasive ductal carcinoma (IDC), yet ...

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring.

Accurate and in situ detection of uracil-DNA glycosylase (UDG) is crucial for clinical diagnosis and...

A Progression-Associated Tumor-Reactive T-Cell Signature Predicts Immunotherapy Response and Reveals ICOS-High CD8 T-Cell Functional States in Head and Neck Squamous Cell Carcinoma.

Immune checkpoint blockade has improved outcomes for patients with head and neck squamous cell carci...

Multimodal Magnetic Resonance Imaging and Machine Learning Uncovers Distinct Progression Patterns in Friedreich Ataxia.

BACKGROUND: Friedreich ataxia (FRDA) is a rare neurodegenerative disorder with heterogenous clinical...

Diagnosis of familial hypercholesterolaemia through population screening.

INTRODUCTION: Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by ...

A rapid automated segmentation method for total kidney volume measurement on unenhanced computed tomography in autosomal dominant polycystic kidney disease.

PURPOSE: To develop and validate a fully automated deep learning-based method for total kidney volum...

Moderate-density SNPs combined with machine learning method driven kinship identification and East Asian subpopulations discrimination analysis.

Moderate-density single nucleotide polymorphisms (SNPs) (nearly 2000 SNPs) have shown great forensic...

MicroRNA circuits and regulatory networks: emerging therapeutic paradigm.

MicroRNAs (miRNAs) are small non-coding RNAs whose function is to regulate gene expression post-tran...

Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review).

Benzene is a toxic aromatic hydrocarbon widely used in industrial production, posing a notable occup...

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review).

Quinoline derivatives are a class of heterocycles featuring a fused benzene‑pyridine scaffold that h...

OM-sqPCR enables one-step multiplex quantification of circulating small-RNA subclasses for colorectal cancer classification.

Accurate multiplex quantification of circulating small RNAs (sRNAs) enables comprehensive evaluation...

Smart nanocarriers against MDR-tuberculosis: stimuli-responsive strategies for granuloma penetration and next generation therapy.

Multidrug-resistant tuberculosis (MDR-TB) remains a global health concern due to long treatment dura...

Nanotheragnosis: an emerging frontier review in personalized cancer medicine.

Cancer remains a major cause of global mortality, while late-stage diagnosis and therapeutic resista...

Protein FT-Transformer: Species Classification via Amino Acid-Encoded DNA Sequences.

DNA barcoding is widely used for species identification, yet many computational classifiers continue...

LncRNAs and the Cancer Epitranscriptome: Mechanisms and Therapeutic Potential.

Long non-coding RNAs (lncRNAs) have emerged as critical regulators of the cancer epitranscriptome, o...

Anthropic's AI biolab finds 'CRISPR-like' DNA in viruses. What's next?

Defining the essential genome of diverse phages with phage Tn-seq.

Phages are important drivers of bacterial evolution and have potential as antimicrobials. However, i...