Genetics

From Passive Sampling to Precision Intervention: A Standardized Radiomics-Driven Workflow for Molecularly Adequate Lung Biopsy.

PURPOSE: To develop and temporally validate a predictive framework for molecular adequacy in computed tomography (CT)-guided transthoracic needle biopsy (TTNB) of lung lesions, integrating procedural variables with radiomic features derived from pre-procedural CT imaging. MATERIALS AND METHODS: This observational derivation-validation study included 670 CT-guided TTNB procedures performed in 633 p...

The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer.

BACKGROUND: Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to characterize the role of Frizzled-3 (FZD3), a Wnt receptor, in SCLC progression. METHODS: We analyzed transcriptomic data from 102 SCLC and 55 normal lung tissues retrieved from the Gene Expr...

A decoction-inspired genetic algorithm and PPO reinforcement learning for intelligent molecular discovery: Anti-colorectal cancer candidates from the tiao-pi AnChang formula.

BACKGROUND: Colorectal cancer (CRC) remains among the leading causes of cancer-related mortality worldwide. The TiaoPi AnChang Decoction (TPACD), a tr...

HOW GENETICS CHANGED OR WILL CHANGE THE THERAPY IN THYROID NODULES WITH INDETERMINATE CYTOLOGY.

The incidence of thyroid cancer has risen in recent decades, largely due to the widespread use of increasingly sensitive imaging techniques that have ...

Meta-analysis, WGCNA, and machine learning converge on a four-gene biomarker panel for heat stress tolerance in Solanum lycopersicum.

Heat stress severely compromises growth, reproduction, and yield in Solanum lycopersicum, necessitating the identification of reliable molecular bioma...

Generalist biological artificial intelligence in modeling the language of life.

Generalist biological artificial intelligence (GBAI) represents a transformative approach to modeling the 'language of life'-the flow of information f...

Statistical models to characterize colon tumor stiffness heterogeneity through representative atomic force microscopy maps.

The study of the impact of physical forces and on cells has emerged as a fertile field of investigation. Applications in oncology are especially trans...

VEFill: accurate and generalizable deep mutational scanning score imputation across protein domains.

Deep Mutational Scanning (DMS) assays can systematically assess the effects of amino acid substitutions on protein function, but many datasets have in...

A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.

Novel genomic risk stratification model for primary high-grade malignant peripheral nerve sheath tumor (MPNST).

Risk stratification across the three main clinical subsets of malignant peripheral nerve sheath tumor (MPNST), neurofibromatosis type I (NF1-related),...

[Advances in integrated antimicrobial resistance diagnostics: quantitative, qualitative and AI-driven approaches].

The rapid global increase in antimicrobial resistance complicates the treatment of life-threatening infections and makes fast, reliable antimicrobial ...

Readout of intrinsic and induced DNA shape by homeodomain transcription factor complexes.

Homeodomain transcription factors (TFs) recognize their DNA targets through both sequence-specific base contacts and readout of local DNA shape. While...

Atypical Ductular Reactions Are a Distinct Regenerative Phenomenon in Hepatocellular Carcinoma (HCC) Patients after Transarterial Chemoembolization.

Transarterial chemoembolization (TACE) is increasingly used in patients with hepatocellular carcinoma (HCC), the most frequent primary liver tumor. At...

Integrated machine learning and multi-omics analysis identifies ALOX5 as a potential therapeutic target for tubulointerstitial inflammation in diabetic kidney disease.

Diabetic kidney disease (DKD) is a leading cause of renal failure. Inflammation of the renal tubules and interstitium is a critical factor in the prog...

Bulliform cells: anatomical, physiological, genetic, and computational perspectives on plants' drought adaptation.

This work highlights pollen thermotolerance as vital for reproductive success under heat stress, integrating molecular regulation, gene mapping, and b...

Active Learning-Guided Polymorph Control in Co-Precipitation Synthesis.

Phase control of polymorphic materials is important yet challenging due to the vast synthesis parameter space and the sensitivity of certain phases to...

5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis.

BACKGROUND: Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging or pathological examination. Liquid biopsy has bee...

Operationalising One Health for epidermal parasitic skin diseases: threshold-triggered mass drug administration and a minimal indicator set.

Epidermal parasitic skin diseases (EPSDs)-including scabies, pediculosis, cutaneous leishmaniasis, tungiasis and cutaneous larva migrans-affect millio...

Induced Dipole Calculation with E(3)-Equivariant Neural Networks and Multipole Field Perturbation.

Polarizable force fields based on induced dipoles are widely implemented in molecular dynamics simulations of biological systems to explicitly capture...

DeepIM: Integrating Channel-Spatial Attention with Transformer for DNA i-Motif Folding Status Prediction.

i-Motif (iM), a quadruplex structure formed by C-rich DNA sequences under acidic conditions, is significant for gene expression regulation, telomere s...