Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND: Mycotoxins are toxic secondary metabolites of toxigenic fungi, posing a significant threat to human health due to their widespread contamination in edible and medicinal plants (EMPs) and synergistic toxicity. PURPOSE: This study aims to design a collaborative multi-technology integration strategy for mycotoxin risk assessment and early warning in EMPs. METHOD: Ultra-performance liquid ...
Inosine monophosphate (IMP) is a key umami-related nucleotide that contributes substantially to chicken meat flavor. This study aimed to elucidate the molecular regulatory mechanisms underlying individual variation in breast muscle IMP content in Beijing-You chicken through integrative transcriptomic and metabolomic analysis. A total of 73 male Beijing-You chickens at 135 days of age were phenotyp...
Transcriptional regulation, critical for cellular differentiation and adaptation to environmental changes, involves coordinated interactions among DNA...
Though critical, traditional diagnostic approaches such as X-ray, CT scans, bronchoscopy and tissue biopsy don't reliably detect lung cancer at early ...
Extending surface-enhanced Raman spectroscopy (SERS) from small molecules to macromolecules is important for various applications, yet it remains chal...
Homologous recombination deficiency (HRD) plays a central role in the pathogenesis and therapeutic vulnerability of epithelial ovarian cancer (EOC), p...
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and dysregulated miRNA expression has been implicated in multiple cancer h...
INTRODUCTION: Cancer is a major global health concern, causing millions of deaths each year due to the uncontrolled growth and spread of abnormal cell...
Epilepsy is a chronic neurological disorder causing recurrent seizures. Improved diagnosis and management, including high-resolution imaging, genetic ...
Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promot...
Aging is the strongest risk factor for chronic diseases such as cardiovascular disease, Alzheimer's, and cancer. DNA methylation (DNAm) clocks offer a...
The natural occurrence of 2,6-diaminopurine (Z) as a substitute for adenine (A) in certain bacteriophage genomes has profound evolutionary implication...
Metabolic rewiring, a defining hallmark of cancer, sustains cell proliferation and biosynthesis while coordinating adaptive interactions within the tu...
BACKGROUND: Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysr...
BACKGROUND: Proteins and RNA circulate in plasma and can offer insights into human physiology. Yet, despite their clinical importance, direct comparis...
Advancements in metagenomics have been driven by the continuous development of bioinformatic tools, particularly taxonomic classification software, wh...
Over the past 2 decades, risk stratification in non-muscle-invasive bladder cancer (NMIBC) has evolved considerably, progressing from simple clinico-p...
Cancer is one of the leading causes of death worldwide, and early tumor detection can significantly reduce mortality rates. Liquid biopsy is a minimal...
OBJECTIVE: Drug-resistant epilepsy (DRE) affects approximately one-third of patients with epilepsy. The molecular heterogeneity underlying DRE remains...