Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Trends, Antimicrobial Resistance, and Source Attribution of Campylobacter jejuni and C. coli in Beijing: An 8-Year Molecular Surveillance Study.

OBJECTIVES: Beijing, a large urban center with complex food supply chains, faces increasing challeng...

(1)
Mar 2026 41831655
CRMIPred: Identifying the spatial interactions among cis-regulatory modules via considering their cross-attended epigenetic profiles.

BACKGROUND AND OBJECTIVE: Modular DNA elements known as cis-regulatory modules (CRMs) play central r...

(2)
Mar 2026 41833256
Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data.

Clustering is commonly used in single-cell RNA sequencing (scRNA-seq) to assess cellular heterogenei...

(2)
Mar 2026 41825449
Beyond the baseline: mapping the context-specific regulatory landscape of disease.

Genome-wide association studies have identified thousands of intergenic variants associated with dis...

Mar 2026 41826141
Computational Redesign of an Ancestral Xylose Isomerase: Tuning the Substrate Preference and Thermostability for Biomass Valorization.

Xylose isomerase is a promising biocatalyst for lignocellulose valorization, but natural enzymes are...

(1)
Mar 2026 41817278
RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss.

BACKGROUND: The molecular landscape of lung adenocarcinoma (LUAD) is often illustrated as a driver-o...

Mar 2026 41817586
Multiclass Radiomics-Based Prediction of BRAF Mutation Status in Pediatric Low-Grade Gliomas Using Multisequence MRI.

BACKGROUND AND PURPOSE: Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in chil...

Mar 2026 41819797
Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping.

BACKGROUND: Eosinophilic esophagitis (EoE) and its related subtypes-such as EoE-like esophagitis, ly...

(2)
Mar 2026 41818315
Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model.

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...

Mar 2026 41814716
Identification and validation of ferroptosis-related genes for diabetic nephropathy.

BACKGROUND: Emerging evidence highlights the pivotal role of ferroptosis in the pathophysiology of d...

(2)
Mar 2026 41825713
Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.

Cell migration underlies immune surveillance, tissue repair, embryogenesis, and-when dysregulated-tu...

Mar 2026 41811952
Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, y...

Mar 2026 41811965
G-quadruplexes and i-motifs: Emerging regulatory elements in plant genomes.

G-quadruplexes (G4s) and i-motifs (iMs) are emerging as key cis-regulatory elements in plant genomes...

Mar 2026 41819024
Untangling biological complexity: A deep learning approach to separating multiple signals in single-cell data.

Single-cell RNA sequencing (scRNA-seq) provides an instantaneous snapshot of the transcriptional sta...

Mar 2026 41819074
Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain.

Aging is a major risk factor for neurodegenerative diseases, yet the underlying epigenetic mechanism...

Mar 2026 41819104
Targeting metabolism to combat anticancer and antibacterial drug resistance.

Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutio...

Mar 2026 41820153
BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.

BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acq...

Mar 2026 41807883
Discovery of a new binding site and a possible gain in neomorphic activity in R132H_IDH1.

In the Krebs cycle, isocitrate dehydrogenase 1 (IDH1) catalyses the conversion of isocitrate (ICT) t...

Mar 2026 41808665
Prediction model for periodontitis stage based on the salivary microbiome.

This study aimed to characterize salivary microbiome compositions that can classify periodontal heal...

Mar 2026 41810937
Hybrid seed production: new paradigms and challenges in the twenty-first century.

Hybrid seed technology future depends on integrating advanced genomics, AI-driven breeding, and enab...

(2)
Mar 2026 41811507
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