Genetics

mirtronDB 2.0: enhanced database with novel mirtron discoveries.

MOTIVATION: MirtronDB provides a comprehensive and up-to-date resource for advancing mirtron researc...

Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine.

Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising i...

Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies.

RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS-mitogen-activa...

Structural mining and engineering of metagenome-derived Cas12a orthologs expands the CRISPR genome editing and multiplex diagnostics toolkit.

CRISPR-Cas12a is a compact, RNA-guided nuclease widely deployed in genome editing and molecular diag...

IDH enzyme inhibition in cancer therapy: mechanisms, mutational insights, and effects of IDH inhibitors in glioma, acute myeloid leukemia and chondrosarcoma.

Isocitrate dehydrogenase (IDH) enzymes have recently emerged as a highly promising target for therap...

Population-level structural variant characterization using pangenome graphs.

Population-level structural variant (SV) profiling is crucial in the era of pangenomes. However, ide...

Leveraging proteomics and machine learning for mechanism and biomarker discovery on glioma progression and transformation: from LGG to GBM.

BACKGROUND: Glioma was the most common malignant tumor of the central nervous system in adults. Low-...

Deep learning with limited data: a transfer learning approach for transcriptomic survival prediction.

BACKGROUND: Deep neural networks (DNNs) are promising for analyzing high-dimensional transcriptomic ...

A targeted proteomics assay for the preoperative diagnosis of thyroid nodules.

Accurate preoperative diagnosis of thyroid nodules via fine-needle aspiration (FNA) biopsy remains c...

Computational redesign of a thermostable T7 RNA polymerase.

T7 RNA polymerase (T7 RNAP) is a foundational enzyme for biotechnology, but its utility for many pot...

Staphylococcus aureus resistance to non-β-lactam antibiotics: global genomic epidemiology and machine learning feasibility assessment.

Staphylococcus aureus is increasingly resistant to β-lactam antibiotics, making non-β-lactam cell-wa...

Nanopore direct RNA sequencing for RNA modification analysis: workflow assessment and computational tool benchmarking.

Recent advancements in sequencing technologies have transformed the characterization of genomic and ...

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remode...

The essential role of methylation in maize (Zea mays) defense against the seed-colonizing fungus Aspergillus flavus.

UNLABELLED: The interaction between maize (Zea mays) and Aspergillus species poses a huge threat to ...

OSCAR: A Modular Open-Source Robotic Platform for Biological Laboratories.

Biological research often involves complex, repetitive, and high-throughput manipulations that are w...

SMC4/SMAD3/NF-κB axis drives cervical cancer progression and radioresistance via DNA damage repair and immune modulation.

OBJECTIVE: Cervical cancer remains a significant global health burden, with the molecular determinan...

Resveratrol ameliorates sepsis-induced immune dysfunction by targeting GADD45A to maintain hematopoietic stem cell homeostasis: A predictive study integrating ensemble machine learning, single-cell transcriptomics, and molecular dynamics simulation.

OBJECTIVE: To investigate the potential pharmacological mechanisms of resveratrol (RES) in ameliorat...

High-Fidelity Data Retrieval from Synthetic DNA Pools via Machine Learning Model.

Synthetic DNA offers significant benefits, remarkable information density and long-term stability fo...

Dysbiosis of fecal virome in pediatric Crohn's disease and its dynamic changes during infliximab therapy.

UNLABELLED: The gut virome is an emerging but underexplored component of the human microbiota, espec...

Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".

An Open-Source Pipeline for Calcium Imaging and All-Optical Physiology in Human Stem Cell-Derived Neurons.

High-throughput, single-cell resolution profiling of neuronal activity is critical for understanding...