Latest AI and machine learning research in genetics for healthcare professionals.
Aging proceeds heterogeneously across organs, making chronological age an inadequate measure of physiological decline. The concept of organ biological age (OBA) offers a refined framework to quantify organ-specific functional deterioration. However, current OBA assessments - based on epigenetic, transcriptomic, metabolomic, or imaging data-largely capture the outcomes rather than the onset of agin...
Fish allergy is a common food-related allergic reaction that can lead to serious health issues and poses a significant challenge to global food safety. To facilitate a clear understanding of risk prevention and control for fish allergy, we provide a comprehensive overview of the mechanism underlying fish allergy and the properties of fish allergens, with a dedicated focus on innovative processing ...
Amur grape (Vitis amurensis Rupr.) is widely recognized for its cold tolerance traits and serves as a valuable genetic resource for breeding climate-r...
Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to imp...
Understanding macromolecular structures of proteins and nucleic acids is critical for discerning their functions and biological roles. Advanced techni...
The treatment paradigm for lymphoma, a highly heterogeneous group of hematologic malignancies, has been revolutionized by the development of therapies...
Since their first report in 2007, microfluidic paper-based analytical devices (μPADs) have continued to gain attention as promising tools for point-of...
Despite extensive structural and functional studies, the molecular mechanisms governing G-protein coupled receptor-G (GPCR-G) protein coupling selecti...
BACKGROUND: Colorectal cancer (CRC) represents the third most prevalent malignancy worldwide and accounts for the second-highest cancer-related mortal...
Plasmid-mediated colistin resistance gene mcr has markedly diminished the effectiveness of colistin in managing multidrug-resistant (MDR) Gram-negativ...
EZH2 (Enhancer-Homozygous Protein 2), as a key epigenetic regulator, is closely associated with multiple cancers. Consequently, the design of EZH2-tar...
The fundamental principle that selection acts on a gene's function often assumes implicitly that this function is fixed and intrinsic. However, empiri...
Protein deletions are frequent among both disease-causing and tolerated variants. Several mechanisms at the DNA, RNA and protein levels can lead to de...
Artificial intelligence (AI) technologies have recently undergone transformative growth in capabilities. In human genetics, AI is rapidly advancing ou...
Oral squamous cell carcinoma (OSCC) is a malignant tumor characterized by both clinical and molecular heterogeneity. Its rising global incidence and m...
The increasing demand for cannabidiol (CBD) and the relaxation of legal restrictions have driven the rapid expansion of cannabis research, cultivation...
Large genomes such as the human genome are pervasively transcribed yet encode relatively few unambiguously functional elements. This has led to debate...
BACKGROUND: Focused ultrasound, low-intensity focused ultrasound, and microbubble-enhanced sonoporation are examples of ultrasound-based cancer therap...
BACKGROUND: While immunotherapy has transformed treatment paradigms for cancer, durable response rates remain below 30%. Currently available biomarker...
Deep neural networks can classify ECGs with high accuracy when training data is abundant. Rare conditions like Brugada syndrome, an inherited arrhythm...