Latest AI and machine learning research in genetics for healthcare professionals.
CMV/HIV coinfection markedly exacerbates disease progression, elevates treatment failure risk, and worsens patient outcomes, yet the underlying molecular mechanisms remain incompletely understood-creating an urgent need for targeted host-focused research. This study identifies asparagine synthetase (ASNS) as a pivotal metabolic-signaling hub in coinfection pathogenesis, with critical interactions ...
IgA nephropathy (IgAN) and celiac disease (CeD) are autoimmune disorders characterized by dysregulated immune responses; however, the molecular mechanisms underlying their comorbidity remain incompletely understood. Here, we integrated transcriptomic datasets from IgAN and CeD to perform differential expression analysis, weighted gene co-expression network analysis (WGCNA), functional enrichment a...
Bone metastasis affects approximately 40% of patients with non-small cell lung cancer (NSCLC), significantly impacting patient survival and prognosis....
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) represents a high-risk subtype of AML, characterized by poor prognosis and limite...
BACKGROUND: Vascular dementia (VaD), known for cognitive issues and cerebrovascular irregularities, is a common dementia type, but its molecular under...
DNA-encoded libraries (DELs) combined with machine learning (ML) offer a powerful paradigm for hit identification. However, sequencing-derived enrichm...
BACKGROUND: Colorectal cancer (CRC) remains a leading cause of global cancer mortality, highlighting the need for precise survival prediction to guide...
BACKGROUND: CRISPR-based genetic screening has become a central methodology in functional genomics, enabling systematic interrogation of gene function...
BACKGROUND: Beyond their classical roles in haemostasis and thrombosis, platelets have been recognised as active regulators of immune responses. Howev...
The suprachiasmatic nucleus (SCN) is considered the master pacemaker of the circadian clock in mammals, but our current knowledge of the SCN is mostly...
Exosomes, nano-sized extracellular vesicles secreted by almost all cell types, have emerged as biologically compatible vehicles for targeted drug deli...
Label-free detection of microRNAs (miRNAs) has emerged as a pivotal approach in molecular diagnostics, integrating the programmability of CRISPR syste...
Infertility has emerged as an increasingly serious global public health concern, affecting approximately one in six individuals of reproductive age wo...
Lactic acid bacteria (LAB) have transitioned from their traditional roles in food preservation and flavor enhancement to more advanced applications su...
Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Trad...
MOTIVATION: G-quadruplex-binding proteins (G4BPs) play key roles in RNA metabolism and stress response, yet their identification remains experimentall...
The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcription control. However, capturing transcriptome, epig...
Accurate cell-type deconvolution is critical for correct interpretation of Epigenome-Wide Association Studies. For all cell-type deconvolution tasks, ...
PIWI proteins maintain genome integrity by piRNA-guided cleavage of complementary RNA targets. While Cleave-N'-Seq (CNS-seq) has advanced our understa...
BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, bu...