Latest AI and machine learning research in genetics for healthcare professionals.
PURPOSE: This study aimed to investigate the potential link between age-related macular degeneration (AMD) and systemic lupus erythematosus (SLE), exploring whether AMD may share underlying autoimmune mechanisms with SLE. The objective was to identify shared core genes and potential diagnostic biomarkers for both diseases. METHODS: We utilized GEO datasets to develop diagnostic models and performe...
BACKGROUND: Emerging evidence highlights the significant role of Neutrophil Extracellular Traps (NETs) in hepatocellular carcinoma (HCC), but the underlying molecular mechanisms involving NETs formation remain incompletely understood. This study aims to identify key biomarkers related to NETs in HCC through bioinformatic analysis. METHODS: We obtained RNA sequencing data of hepatocellular carcinom...
UNLABELLED: Cure rates for childhood malignancies using established therapy protocols have increased to an average of 80% but have reached a plateau. ...
OBJECTIVE: Genomic sequencing leaves >50% of dystonia-affected individuals without a diagnosis. Where DNA-oriented approaches remain insufficient, int...
Advances in sequencing technologies have enhanced the understanding of gene regulation in cells. In particular, Perturb-seq has enabled high-resolutio...
PURPOSE: Radiation-induced meningiomas (RIMs) are an uncommon late complication of cranial irradiation that frequently display aggressive behavior. Al...
CRISPR-Cas enzymes must recognize a protospacer-adjacent motif (PAM) to edit a genomic site, greatly limiting the range of targetable sequences in a g...
BACKGROUND: Cardiovascular disease remains a major source of morbidity and mortality, and population imaging studies have yielded insights into diseas...
Psoriasis is a skin disorder which mainly occurs as a rash, scaly areas and an itchy skin. The symptoms usually occur on the chest, elbows, and the sc...
Convergent phenotypic evolution, the independent acquisition of similar or nearly identical traits in multiple species, is widespread throughout the t...
BACKGROUND: The Nonalcoholic fatty liver disease (NAFLD) is a major chronic liver condition, with its pathology remaining elusive. Consequently, a tho...
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are two key nephrotic syndrome types with significant clinical implications...
BACKGROUND: Gliomas are the most common primary brain tumors, exhibiting significant phenotypic variability even within the same grade. Identifying gl...
Crops increasingly face overlapping stresses such as heat, drought, salinity, and pathogens that conventional breeding or genome editing rarely overco...
OBJECTIVE: In this study, we aimed to develop a method for predicting the response of patients to three commonly used anti-epileptic drugs (AEDs), nam...
The epidermal growth factor receptor (EGFR) is a key target in cancer therapy, mainly in non-small cell lung cancer (NSCLC). Though, the efficacy of E...
BACKGROUND AND AIMS: Early detection of individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is important as intervention...
Many epigenetic drugs lack specificity, which may lead to drug resistance and long-term safety concerns. There is an urgent need to develop more preci...
Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor-derived fragments that persist after treatment and remain unde...
Lung squamous cell carcinoma (LUSC) has a poor prognosis due to the lack of effective targeted therapies, and its incidence has increased dramatically...