Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Showing 2647-2667 of 11,662 articles
Minimal residual disease in solid tumors: Clinical applications and future directions.

Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor-derived frag...

(2)
Feb 2026 41604278
The Immuno-Metabolic Crosstalk in Lung Squamous Cell Carcinoma: Prognostic Insights and Therapeutic Clues.

Lung squamous cell carcinoma (LUSC) has a poor prognosis due to the lack of effective targeted thera...

(1)
Feb 2026 41606426
Comprehensive bioinformatic analysis and experimental validation identify MT1M and MT1X as key metallothioneins in BC pathogenesis.

BACKGROUND: Metallothioneins (MTs) are crucial metal-binding proteins involved in cellular zinc home...

Jan 2026 41666661
Disulfidptosis in osteoarthritis: Role of SLC2A3 downregulation and potential therapeutic implications.

OBJECTIVE: Disulfidptosis is a newly recognized form of regulated cell death characterized by actin ...

Jan 2026 41628840
CYP2C19 genotype-guided dosing of proton pump inhibitors: progress in clinical trials and real-world use.

INTRODUCTION: Proton pump inhibitors (PPIs) are widely used to treat acid-related disorders; however...

Jan 2026 41618926
A novel signature of palmitoylation for predicting prognosis and therapeutic response of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) represents an extremely complex and heterogeneous malignant tumor. Pr...

Jan 2026 41619135
PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3' end sequencing data.

Alternative polyadenylation (APA) is a pervasive RNA-processing mechanism in eukaryotes that signifi...

Jan 2026 41620776
A novel explainable deep-learning approach for network analysis of epistatic interactions.

Epistatic interactions of gene loci often determine complex trait phenotypes and may indicate the un...

Jan 2026 41625145
Advancing climate-resilient livestock systems: Next-generation emission mitigation strategies and integrated technological innovations.

Livestock production significantly contributes to global greenhouse gas (GHG) emissions, particularl...

Jan 2026 41705029
Circulating tumor DNA dynamics predict pathological response and guide therapy personalization in the neoadjuvant setting.

Neoadjuvant therapy is a cornerstone of modern oncology, yet its efficacy is traditionally assessed ...

Jan 2026 41611911
Discovery and cultivation of prokaryotic taxa in the age of metagenomics and artificial intelligence.

Despite advances in sequencing, microbial genomics, and cultivation techniques, the vast majority of...

Jan 2026 41615027
RNA modifications in cancer and their detection: a review.

Ribonucleic acid (RNA) modifications, once viewed as static structural features, are now recognized ...

(1)
Jan 2026 41615068
Update of the Novara Cohort Study (NCS): protocol evolution of a population-based longitudinal study on ageing in Northern Italy - cohort profile.

PURPOSE: The Novara Cohort Study (NCS) was established to investigate the biological, psychological ...

Jan 2026 41617235
Identification of diagnostic and prognostic biomarkers in lung adenocarcinoma through integrated bioinformatics analysis and real time PCR validation.

Lung cancer is the third most common cancer in the US with a 5-year survival rate of 17%. Non-small ...

Jan 2026 41617774
RNA2seg: a generalist model for cell segmentation in image-based spatial transcriptomics.

Imaging-based spatial transcriptomics enables high-resolution spatial mapping of RNA species. A key ...

Jan 2026 41618375
Parameter-efficient fine-tuning enables scalable transfer of regulatory sequence models to novel contexts.

BACKGROUND: DNA sequence deep learning models can accurately predict epigenetic and transcriptional ...

Jan 2026 41618434
Hemoglobin as a Molecular Glue: Toward Potent Inhibition of HbS Polymerization in Sickle Cell Disease.

Sickle cell disease (SCD), a monogenic disorder arising from a single point mutation in the β-globin...

Jan 2026 41612602
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