Latest AI and machine learning research in genetics for healthcare professionals.
Biofilms are intricate bacterial communities encased in a self-produced extracellular matrix (ECM) of DNA, lipids, proteins, and polysaccharides. The diverse ECM composition across bacterial species significantly influences the progression of biofilm-associated infections, making precise identification crucial for effective treatment. Traditional methods such as biochemical assays, MALDI-TOF mass ...
Single-cell multimodal analysis based on machine learning integrates data from multiple modalities such as cell morphological features, gene expression, proteomics, and metabolomics and observes single cells from multiple dimensions. This multi-dimensional features method can accurately capture the differences between cells and enable us to understand cell heterogeneity deeply. However, the acquis...
This comprehensive review focuses on the use of knowledge graphs and Graph Neural Networks (GNNs) to integrate multi-omics data in the field of person...
Gene sequence prediction not only effectively identifies homologous genes but also provides crucial insights into gene function and evolutionary relat...
PURPOSE: AlphaMissense is a newer deep learning-based variant predictor that evaluates the structural consequences of missense variants, the most comm...
BACKGROUND: Non-small cell lung cancer (NSCLC) patients undergoing neoadjuvant chemotherapy (NACT) followed by surgery represent an ideal clinical set...
The CRISPR/Cas9 system is a powerful gene-editing tool. Its specificity and stability rely on complex allosteric regulation. Understanding these allos...
Although metastasis-initiating cells drive metastasis, only a certain subpopulation of these cells can successfully disseminate from the primary tumor...
Zoonotic diseases continue to rise globally, yet no existing genomic tool integrates virulence, antimicrobial resistance (AMR), and mobile genetic ele...
The proliferation of antibiotic resistance genes (ARGs) in environment poses a threat to global public health. Although microbial fuel cell (MFC) has ...
KEY POINTS: TraceOrg is a web-based tool that automatically labels kidney, liver, and cysts, reporting volumes and Mayo Imaging Classification. Extern...
Rice cooking and eating quality (CEQ), a core agronomic trait tied to consumer preference and market value, is regulated by endosperm starch, protein,...
Recently, with the rapid advancement of multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, new tools and app...
BACKGROUND: Periodontitis (PD) is a chronic inflammatory disease marked by immune dysregulation and progressive tissue destruction. Macrophages play a...
BACKGROUND: Takotsubo cardiomyopathy (TTC) is an acute, reversible cardiac syndrome triggered by physical or emotional stress, involving complex multi...
Stalk rot, primarily caused by Fusarium graminearum (Fg) and Pythium inflatum (Pi), is a major maize disease responsible for significant yield losses....
The high heterogeneity of Hepatocellular Carcinoma (HCC) severely hampers clinical outcomes. Current classifications based on gene expression profiles...
As an endocrine-disrupting chemical, 4-nonylphenol (4-NP) has been found above safe limits in global water systems and associated with cancer progress...