Genetics

Quantitative magnetic resonance imaging radiomics predicts photoreceptorness status in retinoblastoma.

BACKGROUND: Molecular characteristics of retinoblastoma cannot be assessed before treatment because tumor biopsy is contraindicated. Photoreceptorness reflects photoreceptor-related gene expression and tumor differentiation. Non-invasive imaging biomarkers that capture this biology are therefore needed. OBJECTIVE: To evaluate whether quantitative radiomics derived from pretreatment magnetic resona...

Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus.

Bisphenol A (BPA) exposure is associated with gestational diabetes mellitus (GDM); however, the underlying molecular mechanisms remain elusive. This study aimed to identify key genes mediating BPA exposure-related GDM through integrative bioinformatics analysis. We integrated BPA-related targets from multiple databases with GDM-associated genes derived from GeneCards and the GSE103552 dataset. Fun...

Mul-PheG2P: decoupled learning and prediction-space fusion enables robust and interpretable multi-phenotype genomic prediction.

Genomic prediction of multiple phenotypes is crucial in modern plant breeding; however, existing methods struggle with negative transfer and lack inte...

Theranostic innovation in infectious lung diseases: integrating biotechnology and nanotechnology for precision medicine.

INTRODUCTION: Introduction: Infectious lung diseases, including pneumonia, tuberculosis (TB), COVID-19, influenza, and emerging fungal infections, are...

Toward the prevention of clinically manifest Parkinson's disease.

Parkinson's disease (PD) is the fastest growing neurological disorder worldwide and is projected to affect unprecedented numbers of individuals by 205...

Phage as a prospective arsenal against superbugs.

The escalating crisis of antimicrobial resistance (AMR) necessitates the urgent development of alternatives to traditional antibiotics. Bacteriophage ...

Engineering monosex and sterile fish for food production: from conventional methods to CRISPR-based precision.

Monosex and sterile fish populations are increasingly recognized as essential tools for enhancing aquaculture productivity while safeguarding ecosyste...

SNP discovery and applications in plant genetics for sustainable food security: A review.

Single nucleotide polymorphisms represent the most abundant form of genetic variation in plant genomes and have become fundamental markers in modern p...

Engineering Organoid Platforms for Pathogenesis Research.

Emerging and re-emerging infectious diseases ranging from the 1918 H1N1 influenza pandemic to the recent SARS-CoV-2 and monkeypox virus outbreaks cont...

Kidney-specific deletion of the BicC family RNA-binding protein 1 triggers an ADPKD-like cystogenic program.

Autosomal dominant polycystic kidney disease (ADPKD) arises from mutations in polycystin-1/PKD1 or polycystin-2/PKD2 that induce injury-repair pathway...

Integrative multi-omics reveals a prognostic and therapeutic landscape of synthetic lethality-associated signatures in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) exhibits considerable heterogeneity and therapeutic resistance. Here, we integrated single-cell RNA sequencing, spatial tra...

Predicting antifouling paint particle contamination based on 16S rRNA gene sequencing data using random forest-based machine learning.

Antifouling paints often contain biocides designed to inhibit biological growth, and antifouling paint particles (APPs) have been previously shown to ...

UCtracker: A Deep Learning-Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study.

Noninvasive diagnosis and longitudinal surveillance of urothelial carcinoma (UC) remain clinically challenging. Here, we developed and prospectively v...

Prognostication in Autosomal Dominant Polycystic Kidney Disease: Current Tools, Clinical Gaps, and Future Directions.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most prevalent hereditary kidney disorder. While the disease is well-defined, its clinical...

Deep learning-supported image quantification of epithelial cell shapes and its application to polycystic kidney disease.

Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and apical junctio...

Integrative transcriptomics and single-cell analysis identify SIX4 as a candidate epithelial target in ovarian cancer and PCOS-associated ovarian dysregulation.

PURPOSE: Ovarian cancer is a heterogeneous solid tumor, whereas polycystic ovary syndrome (PCOS) is a distinct endocrine-metabolic ovarian disorder. W...

Advances in RNA pesticides and nano-delivery systems.

RNA pesticides have garnered considerable attention in pest management due to their exceptional selectivity, environmental safety, and flexible design...

CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.

AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, extensive perineural invasion (PNI), ...

Intron retention in health and amyotrophic lateral sclerosis.

Intron retention (IR) is the molecular phenomenon by which introns, historically thought to represent non-coding 'junk', remain unspliced within pre-m...

Cancer drug response and resistance: molecular mechanisms and combating strategies.

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a fo...