Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.

BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, chara...

May 2025 40475768
Genetic Risk Scores in Stroke Research and Care.

Stroke remains a leading cause of death and disability worldwide. While well-established risk factor...

May 2025 40396275
Intent to Cure: The Need for a Rare Disease Platform in India and Across the Global South.

The democratization of genomic technologies presents substantial opportunities for addressing rare g...

(1)
May 2025 40397096
Making Sense of Missense: Benchmarking MutScore for Variant Interpretation in Inherited Cardiac Diseases.

BACKGROUND: Accurate interpretation of genetic variants still represents a major challenge. Accordin...

(1)
May 2025 40397311
The Role of HbA1c in Parkinson's Disease: An Integrative Analysis by Single-Cell, Bulk Transcriptome and Mendelian Randomization.

Decreased glucose tolerance is recognized as a factor associated with Parkinson's disease (PD) progr...

(1)
May 2025 40397357
RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study.

BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that...

(1)
May 2025 40399884
Investigating the paternal genetic structure and migration history of Chinese Qiang minority by Y-chromosome short tandem repeats.

Known for its legendary history and peculiar culture, Chinese Qiang minority aroused interest among ...

(1)
May 2025 40400520
Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm.

BackgroundNon-invasive methods with universal prognostic guidance for detecting breast cancer (BC) s...

(4)
May 2025 40395152
A pathway-informed disease-related gene identification approach and its application to screen novel risk genes for Alzheimer's disease.

BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disorder, yet its molecular mecha...

May 2025 40406678
Imaging patterns and recommendations for diagnosis, staging, and management of lung cancer.

Lung cancer is the second most commonly diagnosed cancer worldwide. In the present era of targeted t...

May 2025 40486071
Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show th...

May 2025 40391895
Genomics-assisted breeding for designing salinity-smart future crops.

Climate change induces many abiotic stresses, including soil salinity, significantly challenging glo...

May 2025 40390692
An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples.

Circulating tumor DNA is a critical biomarker in cancer diagnostics, but its accurate interpretation...

May 2025 40394286
CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

The large-scale application of the mammalian methylation array has substantially expanded the availa...

May 2025 40394556
Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex mol...

(2)
May 2025 40428167
Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer.

BACKGROUND: Ovarian cancer (OC), a common fatal malignancy in women, has a poor prognosis. RNA modif...

(1)
May 2025 40417417
Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein.

Cytoskeletal motor protein dynein belongs to the AAA+ superfamily of enzymes, functioning as a mecha...

May 2025 40529183
Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder influenced by genetic, epige...

May 2025 40384623
The Future of Parasomnias.

Parasomnias are abnormal behaviours or mental experiences during sleep or the sleep-wake transition....

(2)
May 2025 40387303
Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib.

OBJECTIVE: Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK...

(1)
May 2025 40388487
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