Genetics

A computed tomography-based radiomics prediction model for BRAF mutation status in colorectal cancer.

PURPOSE: The aim of this study was to develop and validate CT venous phase image-based radiomics to predict BRAF gene mutation status in preoperative colorectal cancer patients.

Integrating Network Analysis and Machine Learning to Elucidate Chemical-Induced Pancreatic Toxicity in Zebrafish Embryos.

Zebrafish (Danio rerio) are a popular vertebrate model for high-throughput toxicity testing, serving as a model for embryonic development and disease etiology. However, standardized protocols using zebrafish tend to explore pathologies and behaviors at the organism level, rather than at the organ-specific level. This study investigates the effects of chemical exposures on pancreatic function in wh...

Deciphering Shared Gene Signatures and Immune Infiltration Characteristics Between Gestational Diabetes Mellitus and Preeclampsia by Integrated Bioinformatics Analysis and Machine Learning.

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common and serious disorders of pregnancy that threaten maternal safety and perinatal ou...

3D-ΔΔG: A Dual-Channel Prediction Model for Protein-Protein Binding Affinity Changes Following Mutation Based on Protein 3D Structures.

Protein-protein interactions are crucial for cellular regulation, antigen-antibody interactions, and other vital processes within living organisms. Ho...

Perspectives on the Current and Future State of Artificial Intelligence in Medical Genetics.

Artificial intelligence (AI) is rapidly transforming numerous aspects of daily life, including clinical practice and biomedical research. In light of ...

Deciphering the Immunomodulatory Function of GSN Inflammatory Cancer-Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan-Cancer Single-Cell Landscape and Spatial Transcriptomics Analysis.

The heterogeneity of cancer-associated fibroblasts (CAFs) could affect the response to immune checkpoint inhibitor (ICI) therapy. However, limited stu...

SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness.

The COVID-19 pandemic has prompted an unprecedented global response. In particular, extraordinary efforts have been dedicated toward monitoring and pr...

External Validation of a CT-Based Radiogenomics Model for the Detection of EGFR Mutation in NSCLC and the Impact of Prevalence in Model Building by Using Synthetic Minority Over Sampling (SMOTE): Lessons Learned.

RATIONALE AND OBJECTIVES: Radiogenomics holds promise in identifying molecular alterations in nonsmall cell lung cancer (NSCLC) using imaging features...

SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome viru...

Multiple Mutations in the β1 Subunit of the Nicotinic Acetylcholine Receptor Confer Resistance to Neonicotinoids.

The evolution of resistance to neonicotinoid insecticides threatens global agriculture. To elucidate its molecular basis, we employed as a model syst...

Surveillance of SARS-CoV-2 RNA in wastewater treatment plants in Türkiye, Istanbul: a long-term study and statistical analysis.

Wastewater-based epidemiology (WBE) is a powerful method that allows community surveillance to identify diseases/pandemic dynamics in a city, especial...

Multiplex PCR-Liquid Chromatography High-Resolution Tandem Mass Spectrometry for Simultaneous Detection of Multiple Transgenes in Equine Plasma.

The development of gene therapy techniques introduces a potential risk of gene doping, which threatens the integrity of sport. In response to this cha...

A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer ...

Hormonal regulation and expression dynamics of Bmp4 in the reproductive cycle of Pampus argenteus.

As a member of the bone morphogenetic protein (BMP) family, Bmp4 plays a crucial role in bone formation, early developmental stage and the regulation ...

From Multi-Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR-T Cell Therapy.

Chimeric antigen receptor T (CAR-T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological ma...

Forensic odontology: a comprehensive review of advances and applications in dental forensic medicine.

Forensic odontology is essential in medico-legal investigations, aiding in the identification of individuals, particularly in cases involving decompos...

Simultaneous quantitative detection of viable Salmonella spp., Shiga toxin-producing Escherichia coli, Bacillus cereus, and Listeria monocytogenes in milk through multiplex real-time PCR.

In our study, a multiplex real-time polymerase chain reaction (mRT-PCR)-based method was established to detect viable Salmonella spp. (SS), Shiga toxi...

Polysorbates and poloxamer rescue filter-induced serotype-dependent loss of AAVs.

Adeno-associated viruses (AAVs) are the leading viral vector for in-vivo gene therapy, and their use is expected to grow rapidly in the next decade. W...

Semen collection, semen analysis and artificial insemination in the kākāpō (Strigops habroptilus) to support its conservation.

The critically endangered kākāpō (Strigops habroptilus) has suffered population declines due to habitat loss, hunting, and predation. Conservation eff...

Isolation and characterization of a bioactive compound from Sphingomonas sanguinis DM with cytotoxic and molecular docking analysis.

Datura metel, a common plant in the Solanaceae family, is known for its valuable medicinal properties. The metabolites created by its rhizosphere bact...