Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND: Lipid droplet (LD)-associated metabolic reprogramming plays a critical role in breast cancer progression and immune modulation, yet robust prognostic biomarkers and their functional mechanisms remain incompletely understood. This study aimed to identify LD-associated biomarkers with prognostic and therapeutic relevance through multi-omics integration and functional validation. METHODS:...
Influenza A viruses (IAVs) remain a persistent global threat because of rapid antigenic change, frequent genetic reassortment, and cross-species transmission. Swine act as key "mixing vessels," permitting co-infection with avian and human strains and accelerating viral diversification and zoonotic risk. Effective veterinary surveillance is therefore critical for detecting viral evolution within sw...
DNA methylation is an established biomarker of human ageing and is used by a variety of tools to identify meaningful epigenetic signals. We investigat...
Spinocerebellar ataxia type 8 (SCA8) is traditionally characterized as a cerebellar syndrome, yet emerging evidence suggests significant phenotypic he...
PURPOSE: POSEIDON (NCT03164616) was a randomized, open-label, multicenter phase 3 trial comparing first-line durvalumab with or without tremelimumab i...
SUMMARY: The field of machine learning in antimicrobial resistance (AMR) research has experienced rapid growth, fueled by advancements in high-through...
BACKGROUND: Centrosome-related genes (CRGs) regulate cell division and genomic stability and may influence tumor progression, but their prognostic and...
BACKGROUND: PCLAF (PCNA clamp-associated factor) is a protein involved in DNA replication and DNA repair. Aberrant PCLAF expression has been reported ...
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a poor prognosis. The absence of effective targeted therapies and end...
The population of Vietnam remains underrepresented in global genomic databases. Here, we present VN1K, a resource of multi-omics and phenotypic inform...
Achieving high specificity in biochemical transformations is crucial for research and therapeutics. This is particularly important for genome editing,...
BACKGROUND: DNA replication is a biological process in which a single DNA molecule is duplicated, initiating from multiple genomic sites known as repl...
Antibiotic heteroresistance is a form of within-isolate susceptibility heterogeneity in which an apparently susceptible bacterial population contains ...
Soils are among the most biodiverse ecosystems on the planet, home to staggering amounts of small organisms. Many of these organisms are not known to ...
Keratins (KRTs) are intermediate filament proteins expressed in epithelial cells and serve as diagnostic cancer biomarkers. They serve pivotal roles i...
BACKGROUND: Nurses contribute across the precision cancer care pathway, providing continuous, person-centred care and supporting genomic testing integ...
Reliable chronological frameworks are fundamental for reconstructing Quaternary environmental change, paleoclimate evolution, landscape development, a...
BACKGROUND & AIM: Microvascular invasion (MVI) is a critical prognostic risk factor in hepatocellular carcinoma (HCC). This study evaluated the perfor...
Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-negative breast cancer (TNBC), yet primary and acqu...