Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Showing 4726-4746 of 11,117 articles
Machine learning based CRISPR gRNA design for therapeutic exon skipping.

Restoring gene function by the induced skipping of deleterious exons has been shown to be effective ...

Jan 2021 33417623
TargetDBP+: Enhancing the Performance of Identifying DNA-Binding Proteins via Weighted Convolutional Features.

Protein-DNA interactions exist ubiquitously and play important roles in the life cycles of living ce...

Jan 2021 33410688
An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding.

BACKGROUND: Transcription factor (TF) binding specificity is determined via a complex interplay betw...

Jan 2021 33413545
Optimal tuning of weighted kNN- and diffusion-based methods for denoising single cell genomics data.

The analysis of single-cell genomics data presents several statistical challenges, and extensive eff...

Jan 2021 33411784
PCirc: random forest-based plant circRNA identification software.

BACKGROUND: Circular RNA (circRNA) is a novel type of RNA with a closed-loop structure. Increasing n...

Jan 2021 33407069
A review of deep learning applications for genomic selection.

BACKGROUND: Several conventional genomic Bayesian (or no Bayesian) prediction methods have been prop...

Jan 2021 33407114
Generating real-world evidence from unstructured clinical notes to examine clinical utility of genetic tests: use case in BRCAness.

BACKGROUND: Next-generation sequencing provides comprehensive information about individuals' genetic...

Jan 2021 33407429
Discovering and Visualizing Disease-Specific Electrocardiogram Features Using Deep Learning: Proof-of-Concept in Phospholamban Gene Mutation Carriers.

BACKGROUND: ECG interpretation requires expertise and is mostly based on physician recognition of sp...

Jan 2021 33401921
Osteoarthritis year in review 2020: imaging.

This narrative "Year in Review" highlights a selection of articles published between January 2019 an...

Jan 2021 33418028
iPTT(2 L)-CNN: A Two-Layer Predictor for Identifying Promoters and Their Types in Plant Genomes by Convolutional Neural Network.

A promoter is a short DNA sequence near to the start codon, responsible for initiating transcription...

Jan 2021 33488763
Learning Student Networks via Feature Embedding.

Deep convolutional neural networks have been widely used in numerous applications, but their demandi...

Jan 2021 32092018
sgRNACNN: identifying sgRNA on-target activity in four crops using ensembles of convolutional neural networks.

We proposed an ensemble convolutional neural network model to identify sgRNA high on-target activity...

Jan 2021 33385273
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.

Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous c...

Jan 2021 33391473
Evolution of drug resistance in HIV protease.

BACKGROUND: Drug resistance is a critical problem limiting effective antiviral therapy for HIV/AIDS....

Dec 2020 33375936
Semi-supervised learning for somatic variant calling and peptide identification in personalized cancer immunotherapy.

BACKGROUND: Personalized cancer vaccines are emerging as one of the most promising approaches to imm...

Dec 2020 33375939
Machine learning approaches for crop improvement: Leveraging phenotypic and genotypic big data.

Highly efficient and accurate selection of elite genotypes can lead to dramatic shortening of the br...

Dec 2020 33385619
Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications.

In this study, we proposed a systems biology approach to investigate the pathogenic mechanism for id...

Dec 2020 33375269
Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure.

Heart failure is a global health problem that affects approximately 26 million people worldwide. As ...

Dec 2020 33401250
Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs.

The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19)...

Dec 2020 33361777
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