Genetics

Heterogeneous Multi-Layered Network Model for Omics Data Integration and Analysis.

Advances in next-generation sequencing and high-throughput techniques have enabled the generation of...

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals.

Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but id...

Deep learning for plant genomics and crop improvement.

Our era has witnessed tremendous advances in plant genomics, characterized by an explosion of high-t...

Design of (quinolin-4-ylthio)carboxylic acids as new Escherichia coli DNA gyrase B inhibitors: machine learning studies, molecular docking, synthesis and biological testing.

Spread of multidrug-resistant Escherichia coli clinical isolates is a main problem in the treatment ...

Genome-scale transcriptional dynamics and environmental biosensing.

Genome-scale technologies have enabled mapping of the complex molecular networks that govern cellula...

Next-generation drug repurposing using human genetics and network biology.

Drug repurposing has attracted increased attention, especially in the context of drug discovery rate...

Prognostic factors of Rapid symptoms progression in patients with newly diagnosed parkinson's disease.

Tracking symptoms progression in the early stages of Parkinson's disease (PD) is a laborious endeavo...

Pilot Study to Establish a Novel Five-Gene Biomarker Panel for Predicting Lymph Node Metastasis in Patients With Early Stage Endometrial Cancer.

In the United States and Europe, endometrial endometrioid carcinoma (EEC) is the most prevalent gyn...

Artificial Intelligence for Cardiac Imaging-Genetics Research.

Cardiovascular conditions remain the leading cause of mortality and morbidity worldwide, with genoty...

Incorporating biological structure into machine learning models in biomedicine.

In biomedical applications of machine learning, relevant information often has a rich structure that...

Integrating Computational Methods to Investigate the Macroecology of Microbiomes.

Studies in microbiology have long been mostly restricted to small spatial scales. However, recent te...

Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.

Over the past several decades, atomistic simulations of biomolecules, whether carried out using mole...

Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep.

Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However,...

Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data.

DNA methylation data-based precision cancer diagnostics is emerging as the state of the art for mole...

VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.

Antimicrobial resistance (AMR) is an increasing threat to public health. Current methods of determin...

Gait characteristics and clinical relevance of hereditary spinocerebellar ataxia on deep learning.

BACKGROUND: Deep learning has always been at the forefront of scientific research. It has also been ...

pVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens.

Identification of neoantigens is a critical step in predicting response to checkpoint blockade thera...

R/PY-SUMMA: An R/Python Package for Unsupervised Ensemble Learning for Binary Classification Problems in Bioinformatics.

The increasing availability of complex data in biology and medicine has promoted the use of machine ...

A Multiple-Instance Learning-Based Convolutional Neural Network Model to Detect the Mutation in the Histopathology Images of Glioma Tissues.

Robust Prediction of Single and Multiple Point Protein Mutations Stability Changes.

Accurate prediction of protein stability changes resulting from amino acid substitutions is of utmos...

Polymorphism Is Associated with Impaired Oral Clearance of Gliclazide in Healthy Chinese.

BACKGROUND: Previous studies suggest gliclazide is metabolised primarily by CYP2C19 rather than CYP2...