Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified ...

Jul 2019 31316157
PolyCRACKER, a robust method for the unsupervised partitioning of polyploid subgenomes by signatures of repetitive DNA evolution.

BACKGROUND: Our understanding of polyploid genomes is limited by our inability to definitively assig...

Jul 2019 31299888
Multivariate Cluster-Based Multifactor Dimensionality Reduction to Identify Genetic Interactions for Multiple Quantitative Phenotypes.

To understand the pathophysiology of complex diseases, including hypertension, diabetes, and autism,...

Jul 2019 31380425
Future of Radiotherapy in Nasopharyngeal Carcinoma.

Nasopharyngeal carcinoma (NPC) is a malignancy with unique clinical biological profiles such as asso...

Jul 2019 31265322
The optoelectronic microrobot: A versatile toolbox for micromanipulation.

Microrobotics extends the reach of human-controlled machines to submillimeter dimensions. We introdu...

Jul 2019 31289234
Enabling full-length evolutionary profiles based deep convolutional neural network for predicting DNA-binding proteins from sequence.

Sequence based DNA-binding protein (DBP) prediction is a widely studied biological problem. Sliding ...

Jul 2019 31228283
Applying Deep Neural Network Analysis to High-Content Image-Based Assays.

The etiological underpinnings of many CNS disorders are not well understood. This is likely due to t...

Jul 2019 31284814
Deconvolution of autoencoders to learn biological regulatory modules from single cell mRNA sequencing data.

BACKGROUND: Unsupervised machine learning methods (deep learning) have shown their usefulness with n...

Jul 2019 31286861
A practical guide to intelligent image-activated cell sorting.

Intelligent image-activated cell sorting (iIACS) is a machine-intelligence technology that performs ...

Jul 2019 31278398
BioGD: Bio-inspired robust gradient descent.

Recent research in machine learning pointed to the core problem of state-of-the-art models which imp...

Jul 2019 31276469
Microbiome composition and implications for ballast water classification using machine learning.

Ballast water is a vector for global translocation of microorganisms, and should be monitored to pro...

Jul 2019 31326804
Deep learning-based selection of human sperm with high DNA integrity.

Despite the importance of sperm DNA to human reproduction, currently no method exists to assess indi...

Jul 2019 31286067
CT texture analysis for the prediction of KRAS mutation status in colorectal cancer via a machine learning approach.

PURPOSE: This study aimed to investigate whether a machine learning-based computed tomography (CT) t...

Jul 2019 31439256
Cancer classification and pathway discovery using non-negative matrix factorization.

OBJECTIVES: Extracting genetic information from a full range of sequencing data is important for und...

Jul 2019 31271844
Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models.

BACKGROUND: In spite of the abundance of genomic data, predictive models that describe phenotypes as...

Jul 2019 31266445
Machine learning to predict microbial community functions: An analysis of dissolved organic carbon from litter decomposition.

Microbial communities are ubiquitous and often influence macroscopic properties of the ecosystems th...

Jul 2019 31260460
C-HMOSHSSA: Gene selection for cancer classification using multi-objective meta-heuristic and machine learning methods.

BACKGROUND AND OBJECTIVE: Over the last two decades, DNA microarray technology has emerged as a powe...

Jun 2019 31416551
Gene Expression Data Based Deep Learning Model for Accurate Prediction of Drug-Induced Liver Injury in Advance.

Drug-induced liver injury (DILI), one of the most common adverse effects, leads to drug development ...

Jun 2019 31188585
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS).

Cell state-specific promoters constitute essential tools for basic research and biotechnology becaus...

Jun 2019 31253799
Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease.

A central challenge in human genomics is to understand the cellular, evolutionary, and clinical sign...

Jun 2019 31249063
EternaBrain: Automated RNA design through move sets and strategies from an Internet-scale RNA videogame.

Emerging RNA-based approaches to disease detection and gene therapy require RNA sequences that fold ...

Jun 2019 31247029
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