Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Bio-BLIP: A Multimodal Architecture for Transferable Reasoning in Genomic Variant Interpretation

Developing scientific hypotheses in biology requires integrating heterogeneous evidence across DNA s...

MethylCurate: Tool For Dataset Curation and Epigenetic Aging Clock Evaluation

SummaryDNA methylation datasets from public repositories such as NCBI Gene Expression Omnibus are ce...

Mechanistic Dissection of Conformational Transition of Bicyclic Peptide via Molecular Modeling and Deep Learning

Molecular conformations play a critical role in determining molecular properties, such as membrane p...

A multi-omic, spatial, and whole-slide image dataset of lung neuroendocrine tumours from the lungNENomics cohort

Lung neuroendocrine tumours (lung NETs) are rare neoplasms comprising approximately 2% of lung cance...

Pathway-Centric Integration of CRISPR Fitness with Molecular Features Draws Cancer State Maps

Cancer cells display heterogeneous pathway activity that shapes therapeutic vulnerability, but mappi...

Classic machine learning on top of multiple position weight matrices improves genomic prediction of transcription factor binding sites

Motivation: DNA motifs recognised by transcription factors are typically represented as position wei...

Using Deep Learning Models of Gene Regulation to Guide Drug Prioritization

Drug repurposing offers a cost-effective strategy to accelerate therapeutic discovery, but most comp...

PXN Unlocks the Power of Public Gene Expression Data Through Cross-Technology Integration

The immense value of public gene expression repositories is constrained by the lack of compatibility...

SIGNAL: A Scalable, Real-World Model for Rapid Intraoperative Molecular Classification of Gliomas Using Stimulated Raman Histology

Background: Previous machine learning models to intraoperatively predict the molecular status of gli...

Molecular Methods to Detect Vibrio cholerae and Associated Bacteriophages among Diarrheal Patients in Bangladesh

Molecular diagnostics to detect Vibrio cholerae (Vc) may be negatively impacted by pathogen-specific...

A Blood-Based Transcriptomic Signature for PTSD Classification Using Machine Learning

Post-traumatic stress disorder (PTSD) remains a significant psychiatric burden; despite growing biom...

Morphological fingerprints enable machine learning based inference of neuroblastoma cell states without transcriptomics

Inference of cancer cell states is essential for understanding oncogenic mechanisms and predicting c...

Genomic Foundation Models Reveal Chromatin-Domain-Scale Transposable Element Impacts on Rice Genome Architecture

Alignment-based detection of transposable element (TE) insertion polymorphisms suffers from referenc...

LPDP: Inference-Time Reward Control for Variable-Length DNA Generation with Edit Flows

We study the application of recent Edit Flows for inference-time reward control for DNA sequence gen...

Efficient Adjoint Matching for Fine-tuning Diffusion Models

Reward fine-tuning has become a common approach for aligning pretrained diffusion and flow models wi...

RNA-FM: Flow-Matching Generative Model for Genome-wide RNA-Seq Prediction

Histopathology whole-slide images (WSIs) are routinely acquired in clinical practice and contain ric...

Improving Diffusion Posterior Samplers with Lagged Temporal Corrections for Image Restoration

Diffusion-based posterior sampling (PS) is a leading framework for imaging inverse problems, combini...

TMRL: Diffusion Timestep-Modulated Pretraining Enables Exploration for Efficient Policy Finetuning

Fine-tuning pre-trained robot policies with reinforcement learning (RL) often inherits the bottlenec...

DIVER:Diving Deeper into Distilled Data via Expressive Semantic Recovery

Dataset distillation aims to synthesize a compact proxy dataset that is unreadable or non-raw from t...

Cyst-type epithelial heterogeneity shapes therapeutic responsiveness in ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) exhibits substantial interpatient variability i...

Corpus-wide causality: Algorithm design & application for aggregating gene-disease causal evidence

Identifying causal relationships, rather than mere associations, is essential for applications such ...

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