Genetics

LoMuS: Low-Rank Adaptation with Sequence Multi-representation Improves Protein Stability Prediction.

MOTIVATION: Protein folding stability is a key determinant for understanding protein dynamics, including molecular function, pathogenicity, and protein engineering. Yet, accurate prediction of protein stability remains challenging due to high variability in available data, particularly when only sequence information is available and structural knowledge is limited or unavailable. In this work, we ...

Reform of criminal laws in India: Potential impact on the criminal justice system and forensic investigation.

Although India gained independence in 1947, its laws, namely the Indian Penal Code (IPC) of 1860, the Code of Criminal Procedure (CrPC) of 1973 and the Indian Evidence Act (IEA) of 1872, were still in use. These criminal laws were primarily inherited from the statutes that were established during the colonial period. These laws were framed according to the crimes and legal needs of that time. More...

3dDNAi: An Integrated Approach for 3D Structure Prediction of Single-Stranded DNAs.

Machine-learning approaches are now widely used to predict the 3D structures of proteins and RNA molecules. However, prediction accuracy for RNAs is m...

Mind the gap: An embedding guide to safely travel in sequence space.

We present a hybrid approach combining a protein language model (pLM) with Monte Carlo (MC) sampling for generating enzyme mutants free of mutations d...

Accuracy of breast density assessment using artificial intelligence by convolutional neural network for carriers of UGT1A1 polymorphisms with Gilbert's Syndrome - a pilot study.

INTRODUCTION: Gilbert's Syndrome (GS), an indirect hyperbilirubinemia resulting from the reduced hepatic bilirubin-glucuronyltransferase enzyme activi...

TimeSight: Kinetics-aware detection for digital nucleic acid amplification via spatiotemporal convolutional learning.

Digital nucleic acid amplification enables absolute molecular quantification by partitioning samples into thousands of micro-reactions, yet current an...

Deep Learning Predicts Dissimilar DNA-DNA Binding and Engineers Hyperconnected Networks.

Common frameworks in molecular bioengineering and synthetic biology focus on orthogonality, viewing weak or non-specific interactions as problems to a...

Evaluation of targeted Massively Parallel Sequencing methods for forensic metagenomics.

Massively Parallel Sequencing (MPS) is effective for monitoring the microbial composition of environmental samples. Soil microbial signatures are crit...

A Review of microRNAs in the Post-transcriptional Regulation and its Clinical Manifestation in the Polycystic Ovary Syndrome.

MicroRNAs (miRNAs) are single stranded, short, non-coding, and highly conserved RNA molecules with around 22 nucleotides. They regulate gene expressio...

Personalized antiplatelet therapy: are we ready for a precision medicine approach.

Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 inhibitor, remains central to secondary prevention after acute coronary syndrome and ...

Emerging Novel SARS-CoV-2 Subvariants and the Advantages of AI-ML in Deciphering the Mutation Trends, Genomic Surveillance and Vaccine Development.

BACKGROUND AND AIM: The world witnessed COVID-19 in 2025 yet again, a resurgence driven by LF.7 and NB.1.8.1 subvariants of JN.1. With Singapore, Hong...

Dysregulated glucocorticoid-responsive immune genes in peripheral blood mononuclear cells as a shared molecular signature of autism spectrum disorder and irritable bowel syndrome.

BACKGROUND: Autism spectrum disorder (ASD) is frequently accompanied by gastrointestinal (GI) disturbances resembling irritable bowel syndrome (IBS). ...

STAG: Biologically guided spatial transcriptomics prediction via hypergraph learning.

Spatial transcriptomics (ST) enables spatially resolved gene expression profiling within intact tissue sections. However, its widespread adoption is c...

Unveiling the identification of the genetic features and biological characteristics shared between cervical cancer and venous thromboembolism.

OBJECTIVE: The association between cervical cancer (CC) and venous thromboembolism (VTE) has been well documented, but the underlying molecular charac...

Genotype-Specific Electrophysiological Remodeling in PLN R14del Cardiomyopathy: Implications for Precision Antiarrhythmic Therapy.

BACKGROUND: Inherited PLN (phospholamban) R14del variants cause dilated cardiomyopathy with a high burden of malignant ventricular arrhythmias. Howeve...

Engineering EVs Via ZnBGs-Integrated 3D Dynamic Culture for Type II Diabetic Pressure Ulcer Therapy.

Pressure ulcers (PUs) under type II diabetic conditions pose a significant clinical challenge due to damage to the vascular and neural networks, a sit...

Virus infections and cancers: from mechanisms to therapeutics.

Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, car...

Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) by influencing tumor progression, metastasis, and therapy...

Astragalus polysaccharide-based thermoresponsive hydrogel loaded with β-elemene nanoemulsion in combination with anti-PD-L1 therapy for triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is classified as an immunologically cold tumor, which markedly weakens the therapeutic efficacy of immune checkpo...

Radiomics Models as Tools for Predicting Genetic Mutations in Colorectal Cancer: A Systematic Review and Meta-Analysis.

BACKGROUND: The evaluation of genetic mutations is crucial for personalized therapy in colorectal cancer (CRC), but the invasive tissue biopsy is subj...