Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Harnessing DNA Foundation Models for Cross-Species Transcription Factor Binding Site Prediction in Plant Genomes

Accurate prediction of transcription factor binding sites (TFBSs) is crucial for understanding gene ...

AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model

Deep learning models that predict functional genomic measurements from DNA sequence are powerful too...

TU_MyCo-Vision: A Deep Learning Tool for Detection of Cell Morphologies in Fungal Microscopic Images

Morphological switching in response to environmental stimuli is a well-known phenomenon in fungi, le...

Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis

Bacteria use antagonistic interbacterial weapons such as polymorphic toxin secretion systems (TSS) t...

CpGeneAge: multi-omics aging clocks associated with Nf-κB signaling pathway in aging

Aging clocks have emerged as the primary tools for measuring biological aging and have been develope...

Predicting DNA origami stability in physiological media by machine learning

DNA origami nanostructures offer substantial potential as programmable, biocompatible platforms for ...

scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution

Understanding how regulatory DNA elements shape gene expression across individual cells is a fundame...

Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophag...

Replacement of a single residue in an antibody completely abolishes cognate antigen binding, as predicted by theoretical methods

Structural insights into the interaction between antibodies and antigens at the atomic level are piv...

Decoding Breast Cancer Heterogeneity via Multi-Omics Integration and Language Model-Based Interpretation

We present a novel pipeline combining Multi-Omics Factor Analysis (MOFA) and fine-tuned Large Langua...

Investigating the performance of foundation models on human 3’UTR sequences

Foundation models, such as DNABERT and Nucleotide Transformer have recently shaped a new direction i...

Expanding the DNA Motif Lexicon of the Transcriptional Regulatory Code

Transcriptional regulatory sequences in metazoans contain intricate combinations of transcription fa...

scHDeepInsight: A Hierarchical Deep Learning Framework for Precise Immune Cell Annotation in Single-Cell RNA-seq Data

Immune cell classification from single-cell RNA sequencing (scRNA-seq) presents significant challeng...

Allostery is a widespread cause of loss-of-function variant pathogenicity

Allosteric communication between non-contacting sites in proteins plays a fundamental role in biolog...

A scalable computational framework for predicting gene expression from candidate cis-regulatory elements

Deciphering the relationships between cis-regulatory elements (CREs) and target gene expression has ...

LeGO-Teknik reveals that the neurogenesis pathway is a clone-specific hallmark of brain metastasis in breast cancer

Breast cancer exhibits substantial inter- and intra-patient heterogeneity. Yet the molecular feature...

AbAgym: a well-curated dataset for the mutational analysis of antibody-antigen complexes

With monoclonal antibodies becoming one of the largest classes of biopharmaceuticals, it is importan...

Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference

Understanding the ordinal relationships between items requires constructing a rank order supporting ...

Rapid and Reproducible Multimodal Biological Foundation Model Development with AIDO.ModelGenerator

Foundation models (FMs) for DNA, RNA, proteins, cells, and tissues have begun to close long-standing...

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