Genetics

Multi-omics and artificial intelligence nominate PCLAF as a prognostic and druggable target for hepatitis B virus-associated hepatocellular carcinoma.

BACKGROUND: PCLAF (PCNA clamp-associated factor) is a protein involved in DNA replication and DNA re...

VN1K is a pangenome-informed multi-omics and phenomics resource for the Vietnamese population.

The population of Vietnam remains underrepresented in global genomic databases. Here, we present VN1...

AI identifies interactions in CRISPR complexes to improve specificity of DNA editing.

Precise DNA base editing using AlphaFold3-based contact modelling.

Achieving high specificity in biochemical transformations is crucial for research and therapeutics. ...

Interpretable prediction of DNA replication origins in S. cerevisiae using DNABERT and DNABERT-2.

BACKGROUND: DNA replication is a biological process in which a single DNA molecule is duplicated, in...

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.

Antibiotic heteroresistance is a form of within-isolate susceptibility heterogeneity in which an app...

Digital phenotyping accelerates soil biodiversity discovery.

Soils are among the most biodiverse ecosystems on the planet, home to staggering amounts of small or...

Keratin gene expression signature predicts prognosis and immunotherapy efficacy in lung adenocarcinoma.

Keratins (KRTs) are intermediate filament proteins expressed in epithelial cells and serve as diagno...

Nursing roles, competencies, and education in precision oncology: a scoping review.

BACKGROUND: Nurses contribute across the precision cancer care pathway, providing continuous, person...

Recent advances in radioisotope geochronology for quaternary environmental and paleoclimate reconstruction.

Reliable chronological frameworks are fundamental for reconstructing Quaternary environmental change...

cfDNA derived gene signatures as surrogate for microvascular invasion in HCC.

BACKGROUND & AIM: Microvascular invasion (MVI) is a critical prognostic risk factor in hepatocellula...

Recent Advances in Immunotherapy for Breast Cancer: An Updated Review.

Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-n...

A bladder cancer-associated gene signature for exploratory qPCR-based survival stratification in NAC-Treated muscle-invasive bladder cancer.

BACKGROUND: Muscle-invasive bladder cancer (MIBC) is an aggressive and heterogeneous malignancy with...

Artificial Intelligence in Inherited Retinal Diseases: Imaging-Based Applications and Emerging Trends.

INTRODUCTION: Inherited retinal diseases (IRDs) represent a heterogeneous group of progressive disor...

Next-Generation Rapid Pesticide Assays: A Critical Review of Analytical Methods, Detection Limits, and Future Directions.

The large-scale application of pesticides in present-day agriculture renders the demand for prompt, ...

[Optimized regional lymph node management after neoadjuvant therapy in breast cancer].

Neoadjuvant therapy (NAT) has strengthened systemic control in breast cancer and promoted precision ...

Extending Protein Language Models to a Viral Genomic Scale Using Biologically Induced Sparse Attention.

The transformer architecture in deep learning has revolutionized protein sequence analysis. Recent a...

ML-guided screening of chalcogenide perovskites as solar energy materials.

Chalcogenide perovskites have emerged as promising absorber materials for next-generation photovolta...

Machine learning-based identification of lactate metabolism-associated biomarkers in non-alcoholic fatty liver disease.

To determine lactate metabolism-associated biomarkers for non-alcoholic fatty liver disease (NAFLD)....

Integrative Transcriptomic Analysis Identifies a Key Candidate Gene Bridging Inflammation and DNA Repair in Endometriosis.

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by th...

From Variant Interpretation to Biomarker Translation: Multi-omics Integration in Inherited Neuromuscular Diseases.

Genetic neuromuscular diseases are highly heterogeneous disorders characterized by diagnostic challe...