Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning Approach

Due to the late detection, aggressive nature, and paucity of treatment options, pancreatic adenocarc...

Generative design and construction of functional plasmids with a DNA language model

DNA language models offer a new paradigm for sequence design, yet their ability to generate function...

Circuit specific specialization of human basal ganglia astrocytes

Astrocytes shape synapses and circuits, yet human basal ganglia astrocyte diversity is incompletely ...

Deep learning analyses of DNA sequences resolve the retention of the Duffy-null resistance to Plasmodium vivax malaria in Africa

P. vivax, the most geographically widespread human malaria parasite with millions of clinical cases ...

SpatialProp: tissue perturbation modeling with spatially resolved single-cell transcriptomics

Perturbational studies are the gold standard for identifying causal relationships between components...

Colon-Specific Epigenetic Clocks from Minimal Features Reveal Disease-Driven Aging

Epigenetic clocks estimate chronological and biological age from DNA methylation patterns, but conve...

Machine-learning-based determination of sex-related bladder cancer biomarkers

Bladder cancer exhibits sex-specific behavior, occurring more frequently in males but progressing to...

Unimeth: A unified transformer framework for accurate DNA methylation detection from nanopore reads

Nanopore sequencing has emerged as a powerful technology for DNA methylation detection, particularly...

Decoding Prokaryotic Whole Genomes with a Product-Contextualized Large Language Model

Genomes encode the instructions for life, yet their full interpretation requires models capable of c...

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

Diffuse midline glioma (DMG) is a near-universally lethal form of pediatric high-grade glioma, drive...

Acropora millepora’s microbiome is predicted by algal symbionts, host genetics, and environment

The coral microbiome is a critical component of coral health and resilience, yet it is unclear what ...

Integrative metabolome-genome analysis reveals the genetic architecture of metabolic diversity in sorghum grain

Cereal grains are fundamental to global food security and bioenergy production, yet the genetic and ...

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation

Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagat...

TRIO-AI: Hybrid temporal graph, ODE, and VAE modeling for high-resolution cellular trajectory inference in liver injury

Resolving dynamic cellular transitions at single-cell resolution is essential for understanding comp...

LoMuS: Low-Rank Adaptation with Multimodal Representations Improves Protein Stability Prediction

Protein folding stability is a key determinant for understanding protein dynamics, including molecul...

PatchDNA: A Flexible and Biologically-Informed Alternative to Tokenization for DNA

DNA language models are emerging as powerful tools for representing genomic sequences, with recent p...

Design principles of neuromorphic computing using genetic circuits

Cells have evolved to sense a wide range of input combinations and integrate those signals through s...

Evaluation of a structure-based method for ab initio gene detection using deep learning

In this work, a novel method for the detection of exons within genomic DNA sequences was implemented...

Enigma: An Efficient Model for Deciphering Regulatory Genomics

Genomic sequence-to-function models have emerged as powerful tools for deciphering cis-regulatory gr...

AlphaRING-X: accurate interpretation of missense variant deleteriousness based on protein structural stability

Accurate interpretation of missense variants remains a significant challenge hindering genomic diagn...

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