Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Effect of noise in intelligent cellular decision making.

Similar to intelligent multicellular neural networks controlling human brains, even single cells, surprisingly, are able to make intelligent decisions to classify several external stimuli or to associate them. This happens because of the fact that gene regulatory networks can perform as perceptrons, simple intelligent schemes known from studies on Artificial Intelligence. We study the role of gene...

May 12 2015 25965584

Real-time human action classification using a dynamic neural model.

The multiple timescale recurrent neural network (MTRNN) model is a useful tool for recording and regenerating a continuous signal for dynamic tasks. However, our research shows that the MTRNN model is difficult to use for the classification of multiple types of motion when observing a human action. Therefore, in this paper, we propose a new supervised MTRNN model for handling the issue of action c...

May 8 2015 26042805
Machine learning applications in genetics and genomics.

The field of machine learning, which aims to develop computer algorithms that improve with experience, holds promise to enable computers to assist hum...

May 7 2015 25948244
MIMP: predicting the impact of mutations on kinase-substrate phosphorylation.

Protein phosphorylation is important in cellular pathways and altered in disease. We developed MIMP (http://mimp.baderlab.org/), a machine learning me...

May 4 2015 25938373
A global optimization approach to multi-polarity sentiment analysis.

Following the rapid development of social media, sentiment analysis has become an important social media mining technique. The performance of automati...

Apr 24 2015 25909740
Robotic and clinical evaluation of upper limb motor performance in patients with Friedreich's Ataxia: an observational study.

BACKGROUND: Friedreich's ataxia (FRDA) is the most common hereditary autosomal recessive form of ataxia. In this disease there is early manifestation ...

Apr 23 2015 25900021
Cigarette smoke condensate and individual constituents modulate DNA methyltransferase expression in human liver cells.

OBJECTIVES: Previous studies found higher expression levels of DNA methyltransferase 1 in liver samples from smokers compared to those from non-smoker...

Apr 22 2015 26770776
PaPI: pseudo amino acid composition to score human protein-coding variants.

BACKGROUND: High throughput sequencing technologies are able to identify the whole genomic variation of an individual. Gene-targeted and whole-exome e...

Apr 19 2015 25928477
mRMR-ABC: A Hybrid Gene Selection Algorithm for Cancer Classification Using Microarray Gene Expression Profiling.

An artificial bee colony (ABC) is a relatively recent swarm intelligence optimization approach. In this paper, we propose the first attempt at applyin...

Apr 15 2015 25961028
Comparison of Seven Methods for Boolean Factor Analysis and Their Evaluation by Information Gain.

An usual task in large data set analysis is searching for an appropriate data representation in a space of fewer dimensions. One of the most efficient...

Apr 7 2015 25861088
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.

Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imag...

Apr 6 2015 25846798
Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis.

Bio-ontologies provide terminologies for the scientific community to describe biomedical entities in a standardized manner. There are multiple initiat...

Apr 4 2015 25841438
Multiscale Modeling of Gene-Behavior Associations in an Artificial Neural Network Model of Cognitive Development.

In the multidisciplinary field of developmental cognitive neuroscience, statistical associations between levels of description play an increasingly im...

Apr 3 2015 25845802
Printing 2-dimentional droplet array for single-cell reverse transcription quantitative PCR assay with a microfluidic robot.

This paper describes a nanoliter droplet array-based single-cell reverse transcription quantitative PCR (RT-qPCR) assay method for quantifying gene ex...

Apr 1 2015 25828383
Application of neural networks with back-propagation to genome-enabled prediction of complex traits in Holstein-Friesian and German Fleckvieh cattle.

BACKGROUND: Recently, artificial neural networks (ANN) have been proposed as promising machines for marker-based genomic predictions of complex traits...

Mar 31 2015 25886037
Identification of active transcriptional regulatory elements from GRO-seq data.

Modifications to the global run-on and sequencing (GRO-seq) protocol that enrich for 5'-capped RNAs can be used to reveal active transcriptional regul...

Mar 23 2015 25799441
De novo transcriptome assembly of pummelo and molecular marker development.

Pummelo (Citrus grandis) is an important fruit crop worldwide because of its nutritional value. To accelerate the pummelo breeding program, it is esse...

Mar 23 2015 25799271
New enhanced artificial bee colony (JA-ABC5) algorithm with application for reactive power optimization.

The standard artificial bee colony (ABC) algorithm involves exploration and exploitation processes which need to be balanced for enhanced performance....

Mar 23 2015 25879054
Improved feature-based prediction of SNPs in human cytochrome P450 enzymes.

Single nucleotide polymorphisms (SNPs) make up the most common form of mutations in human cytochrome P450 enzymes family, and have the potential to br...

Mar 21 2015 25792441
miRBoost: boosting support vector machines for microRNA precursor classification.

Identification of microRNAs (miRNAs) is an important step toward understanding post-transcriptional gene regulation and miRNA-related pathology. Diffi...

Mar 20 2015 25795417
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