Genetics

Hypoxia tumor-associated macrophages facilitate hepatocellular carcinoma metastasis via uPA-uPAR pathway.

BACKGROUND: Hepatocellular carcinoma (HCC) arises within a hypoxic and immunosuppressive tumor micro...

A serum-clinical composite model for prostate cancer diagnosis: multicenter validation and CRISPR/Cas13a-based detection.

BACKGROUND: Avoidable prostate biopsies remain a persistent weakness of prostate specific antigen (P...

Mechanistic study on comorbidities of kidney stones and sepsis using transcriptome sequencing combined with single-cell spatial transcriptome sequencing.

Kidney stones and sepsis have a complex pathological association. Urinary obstruction and infection ...

The evolving bioinformatic approaches to identifying genetic targets of promise in cancers.

INTRODUCTION: The search for actionable genetic targets in cancer has evolved substantially over the...

CRISPR/cas-based biosensors for point-of-care testing: a comprehensive review of signal readout strategies.

The CRISPR/Cas system has emerged as a transformative tool for nucleic acid detection, offering sign...

GraphGDel: Constructing and Learning Graph Representations of Genome-Scale Metabolic Models for Growth-Coupled Gene Deletion Prediction.

In genome-scale constraint-based metabolic models, gene deletion strategies are essential for achiev...

Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells.

Common genetic variants contribute to risk for complex human diseases. However, despite thousands of...

Mapping ovarian cellular and molecular landscape across the lifespan of women: a scoping review.

BACKGROUND: With growing interest in ART, fertility preservation, and postmenopausal health of women...

Development and Validation of a Multimodal-Multitask Deep Learning Approach for Estimating Late Distant Recurrence Risk in HR-Positive Early Breast Cancer.

Late distant recurrence (DR) remains a persistent risk in hormone receptor-positive (HR+) early brea...

From binary labels to dynamic landscapes: The evolving computational prediction of protein-RNA interactions through tasks and deep learning paradigms.

Protein-RNA interactions (RPIs) stand for the central process in post-transcriptional regulation and...

Multi-omics dissection of panicle development reveals a GSE9-centered regulatory network controlling rice grain shape.

INTRODUCTION: Rice panicle development is a key agronomic trait that critically determining grain yi...

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.

Estrogen receptor 1 (ESR1) is an established oncogenic transcription factor in breast and endometria...

The Spanish Atherosclerosis Society Dyslipidaemia Registry: Evolution, real-world evidence, and its role in precision medicine. Current status in 2026.

INTRODUCTION: The National Dyslipidemia Registry of the Spanish Atherosclerosis Society (SEA) repres...

Multi-omics prediction for yellow rust in bread and durum wheat through conventional and Ai-based frameworks.

Yellow rust (YR) is a major threat to both bread and durum wheat production, often causing substanti...

The future of pediatric gene therapy: CRISPR-Cas9, AI, and personalized medicine.

The future of pediatric gene therapy is being fundamentally reshaped by the convergence of CRISPR-Ca...

Integrated bibliometric and machine learning analyses identify candidate autophagy related therapeutic targets for prostate cancer.

PURPOSE: Autophagy is increasingly recognized as a promising therapeutic target in prostate cancer (...

Key genes identified in ammonia-induced cell death during pediatric sepsis: Machine learning, single-cell, and virtual gene knockout approaches.

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response ...

BoltzOmics: Predicting genetic variant effects on drug binding with Boltz-2.

A mechanistic understanding of how genetic variants alter drug-receptor binding is central to precis...

Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets.

BACKGROUND: Diabetic kidney disease (DKD) is the primary global cause of end-stage renal disease. Ho...

CRISPR gets a power boost from AI-designed 'molecular scissors'.

From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.

The genomic deluge has pushed viral molecular evolution into a site-resolved era. For antigenically ...